Study type: Medical/biological study (experimental study)

Focus formation of C3H/10T1/2 cells and exposure to a 836.55 MHz modulated radiofrequency field med./bio.

By: Cain CD, Thomas DL, Adey WR
Published in: Bioelectromagnetics 1997; 18 (3): 237-243
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Aim of study (acc. to editor)

A cocultured system of C3H 10T1/2 and 10e cells in combination with TPA (a chemical tumor promotor) was used to investigate if RF fields (radiofrequency; 836.55 MHz) influence promotional aspects of in vitro carcinogenesis.

Background/further details

Cocultured 10T1/2 fibroblasts prevent focus formation of mutant UV/TDT10e fibroblast cells. A tumor-promotor (such as TPA) may suspend this inhibition.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 836.55 MHz
Modulation type: pulsed
Exposure duration: 20 min on - 20 min off, 24 h/day for 28 days
  • SAR: 0.15 µW/g average over time
  • SAR: 1.5 µW/g average over time
  • SAR: 15 µW/g average over time

Exposure 1

Main characteristics
Frequency 836.55 MHz
Type
Exposure duration 20 min on - 20 min off, 24 h/day for 28 days
Modulation
Modulation type pulsed
Duty cycle 33 %
Repetition frequency 50 Hz
Additional info

TDMA
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.15 µW/g average over time calculated - -
SAR 1.5 µW/g average over time calculated - -
SAR 15 µW/g average over time calculated - -

Reference articles

  • Ivaschuk OI et al. (1997): Exposure of nerve growth factor-treated PC12 rat pheochromocytoma cells to a modulated radiofrequency field at 836.55 MHz: effects on c-jun and c-fos expression

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No evidence was found that TDMA-modulated RF field influences tumor promotional aspects of in vitro carcinogenesis, based on the RF field's inability to enhance TPA-induced focus formation.

Study character:

Study funded by