Study type: Medical/biological study (experimental study)

Electrical and chemical stimulation of the basolateral complex of the amygdala reinstates cocaine-seeking behavior in the rat med./bio.

By: Hayes RJ, Vorel SR, Spector J, Liu X, Gardner EL
Published in: Psychopharmacology 2003; 168 (1-2): 75-83
Download citation in RIS format

Aim of study (acc. to author)

To determine whether electrical or excitatory amino-acid stimulation of the basolateral complex of the amygdala is sufficient to induce reinstatement of cocaine seeking in rats.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 20 Hz
Modulation type: pulsed
Exposure duration: 200 pulses given at 1 h intervals
  • I = 400 µA
Exposure 2: 2 Hz
Modulation type: pulsed
Exposure duration: 200 pulses given at 1 h intervals
  • I = 400 µA

Exposure 1

Main characteristics
Frequency 20 Hz
Type
Waveform
Exposure duration 200 pulses given at 1 h intervals
Modulation
Modulation type pulsed
Pulse width 0.4 ms
Pulse type rectangular
Exposure setup
Exposure source
Distance between exposed object and exposure source 0.07 m
Chamber 30 cm x 20 cm x 24 cm chambers
Parameters
Measurand Value Type Method Mass Remarks
cf. remarks - - - - I = 400 µA

Exposure 2

Main characteristics
Frequency 2 Hz
Type
Waveform
Exposure duration 200 pulses given at 1 h intervals
Modulation
Modulation type pulsed
Pulse width 0.4 ms
Pulse type rectangular
Exposure setup
Exposure source
Distance between exposed object and exposure source 0.07 m
Parameters
Measurand Value Type Method Mass Remarks
cf. remarks - - - - I = 400 µA

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

It could be demonstrated that electrical or chemical stimulation of the basolateral complex is sufficient to reinstate drug seeking in behaviorally extinguished rats.

Study character:

Study funded by