Study type: Medical/biological study (experimental study)

Microwave attenuation of ethanol-induced interactions with noradrenergic neurotransmitter systems. med./bio.

Published in: Health Phys 1989; 56 (5): 767-776

Aim of study (acc. to author)

Research suggests that microwave exposure can attenuate ethanol-induced hypothermia in a manner that may depend, in part, on noradrenergic neurotransmitter systems. To study this possible interaction, neonatal rats were injected with the neurotoxin 6-hydroxydopamine (6-OHDA) to lesion central noradrenergic neurons and to induce ethanol hypothermia as adults (experiment 1). Additional experiments investigated microwave interactions with centrally and peripherally acting beta-adrenergic antagonists (propranolol and CGP-12177) to antagonize ethanol-induced hypothermia in microwave exposed animals (experiments 2 and 3).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: CW
Exposure duration: 45 min

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Waveform
Exposure duration 45 min
Additional info Circularly polarized.
Modulation
Modulation type CW
Exposure setup
Exposure source
Setup rats placed in Plexiglas hutches
Parameters
Measurand Value Type Method Mass Remarks
SAR 300 µW/g mean calculated - -

Reference articles

  • Guy AW et al. (1979): Circularly polarized 2450 MHz waveguide system for chronic exposure of small animals to microwaves.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • before exposure
  • after exposure

Main outcome of study (acc. to author)

Experiment 1: When tested as adults, lesioned, microwave exposed rats did not show the interaction between microwave and ethanol-induced hypothermia that was seen among control rats. The data of experiment 1 suggest that microwave exposure may act in a manner similar to noradrenergic beta-antagonists.
Experiment 2 and 3: Acute low-level microwave exposure attenuated ethanol-induced hypothermia in the rat. The data confirm that ethanol-induced hypothermia is partially mediated by noradrenergic systems. Pretreatment with the centrally active beta-adrenergic antagonist propranolol significantly attenuated the ethanol-induced hypothermia of sham-exposed animals. There was no consistent effect of propranolol on irradiated rats, regardless of dose. Similarly, the degree of hypothermia demonstrated by sham-exposed controls was significantly attenuated compared to exposed rats by pretreatment with the peripheral beta-adrenergic antagonist CGP-12177.
In conclusion, the findings confirm noradrenergic mediation of ethanol-induced hypothermia and suggest that microwave energy may in some way mimic the role of beta-adrenergic antagonists.

Study character:

Study funded by

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