研究のタイプ: 医学/生物学の研究 (experimental study)

[エタノールが誘発したノリアドレナリン作動性神経伝達物質系との相互作用のマイクロ波による減弱] med./bio.

Microwave attenuation of ethanol-induced interactions with noradrenergic neurotransmitter systems.

掲載誌: Health Phys 1989; 56 (5): 767-776

The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →

研究目的(著者による)

Research suggests that microwave exposure can attenuate ethanol-induced hypothermia in a manner that may depend, in part, on noradrenergic neurotransmitter systems. To study this possible interaction, neonatal rats were injected with the neurotoxin 6-hydroxydopamine (6-OHDA) to lesion central noradrenergic neurons and to induce ethanol hypothermia as adults (experiment 1). Additional experiments investigated microwave interactions with centrally and peripherally acting beta-adrenergic antagonists (propranolol and CGP-12177) to antagonize ethanol-induced hypothermia in microwave exposed animals (experiments 2 and 3).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
Modulation type: CW
ばく露時間: 45 min
  • SAR: 300 µW/g mean

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
波形
  • sinusoidal
ばく露時間 45 min
Additional information Circularly polarized.
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 rats placed in Plexiglas hutches
パラメータ
測定量 種別 Method Mass 備考
SAR 300 µW/g mean 計算値 - -

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露後

研究の主なアウトカム(著者による)

Experiment 1: When tested as adults, lesioned, microwave exposed rats did not show the interaction between microwave and ethanol-induced hypothermia that was seen among control rats. The data of experiment 1 suggest that microwave exposure may act in a manner similar to noradrenergic beta-antagonists.
Experiment 2 and 3: Acute low-level microwave exposure attenuated ethanol-induced hypothermia in the rat. The data confirm that ethanol-induced hypothermia is partially mediated by noradrenergic systems. Pretreatment with the centrally active beta-adrenergic antagonist propranolol significantly attenuated the ethanol-induced hypothermia of sham-exposed animals. There was no consistent effect of propranolol on irradiated rats, regardless of dose. Similarly, the degree of hypothermia demonstrated by sham-exposed controls was significantly attenuated compared to exposed rats by pretreatment with the peripheral beta-adrenergic antagonist CGP-12177.
In conclusion, the findings confirm noradrenergic mediation of ethanol-induced hypothermia and suggest that microwave energy may in some way mimic the role of beta-adrenergic antagonists.

研究の種別:

研究助成

この論文に対するコメント