In previous experiments, the authors found that magnetic fieldexposure might influence the toxicity and the behavioral effects of cocaine in mice. The latter should be closer investigated in this study in view of a possible therapeutic use. 216 mice received intraperitonealinjections of cocaine hydrochloride (either 65 or 70 mg/kg) and were exposed to a magnetic field immediately thereafter. The following groups were used (n=24 each): 65 mg/kg cocaine (n=12) and 70 mg/kg cocaine (n=12) and exposure to a magnetic field of 1) 2 Hz, 2) 3 Hz, 3) 4 Hz, 4) 8 Hz, 5) 10 Hz, 6) 15 Hz, 7) 25 Hz, 8) 60 Hz and 9) sham exposure. The doses of cocaine were chosen because the lethality is around 50%.
5 rectangular coils on 38 x 26 x 38 cm3 with 150 turns on open wooden frames created the fields; 4 vertical wooden supports held the coils, which were set 9.5 cm apart; the homogeneity over the exposed region inside the frame was larger than 95%; mouse cage with one mouse was placed at the center of the coil system; temperature of laboratory was between 26°C and 28°C
BrainKorea21 (BK 21) Project, Korea Research Foundation, Korea
Korea Science and Engineering Foundation
Samsung Advanced Institute of Technology, Korea
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