To study and to compare the effects of 4 Hz and 60 Hz magnetic fields on pentylenetetrazole-induced seizure in mice (6-8 mice per group).
Seizures were induced by pentylenetetrazole injection (85 mg/kg).
| Exposure | Parameters |
|---|---|
|
Exposure 1:
4 Hz
Exposure duration:
continuous for 30 min
|
|
|
Exposure 2:
60 Hz
Exposure duration:
continuous for 30 min
|
|
| Frequency | 4 Hz |
|---|---|
| Type | |
| Exposure duration | continuous for 30 min |
| Exposure source | |
|---|---|
| Setup | two square Helmholtz coils (100 cm x 100 cm) were used; 50 cm apart of each other; animal cage between the coils |
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 2 mT | - | measured | - | - |
| Frequency | 60 Hz |
|---|---|
| Type | |
| Exposure duration | continuous for 30 min |
| Exposure source |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 2 mT | - | measured | - | - |
Compared to sham exposed controls, the latency to tail twitching and seizure in the 4 Hz magnetic field group was significantly decreased while the latent period to seizure in the 60 Hz magnetic field group was significantly increased. Compared to the sham exposure group, the seizure duration times in both magnetic field exposure groups were significantly decreased. Mice exposed to a 60 Hz magnetic field experienced significantly increased lethality after seizure convulsion, while those exposed to a 4 Hz magnetic field showed no lethality.
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