Study type: Medical/biological study (experimental study)

No effect of 50 Hz magnetic field observed in a pilot study on pentylenetetrazol-induced seizures and mortality in mice med./bio.

Published in: Epilepsy Res 2001; 44 (1): 27-32

Aim of study (acc. to author)

To study whether magnetic field exposure has an effect on pentylenetetrazol-induced seizures.

Background/further details

Pentylenetetrazol (PZT)-induced seizures in mice were used as an animal model of epilepsy to study potential therapeutic effects of magnetic fields.
20 female mice were studied in two groups: Group 1 (n=10) was exposed for one hour and after exposure PZT was injected (60 mg/kg) and the mice were observed for 30 minutes. Group 2 (n=10) was sham exposed for one hour before the PZT injection and then observed for 30 minutes.



Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous for 1 h

Exposure 1

Main characteristics
Frequency 50 Hz
Exposure duration continuous for 1 h
Exposure setup
Exposure source
Setup circular pairs of Helmholtz coils with a diameter of 42.75 cm and a clearance of 21.375 cm, made of 154 turns of insulated copper wire; mice placed in the center of the coils
Sham exposure A sham exposure was conducted.
Measurand Value Type Method Mass Remarks
magnetic flux density 200 µT - measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

There was no significant effect of the 50 Hz magnetic field on the number of pentylenetetrazol-induced seizures, seizure latency, total seizure duration and mortality.
The present results failed to provide support for a therapeutic potential of magnetic fields.

Study character:

Study funded by

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