To clarify the effect of extremely low frequency electromagnetic field on microcirculation, acute effects on leukocyte-endothelium interactions resulting from extremely low frequency electromagnetic field exposure were examined in conscious mice.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
50 Hz
Exposure duration:
30 min
|
|
|
Exposure 2:
50 Hz
Exposure duration:
30 min
|
|
|
Exposure 3:
50 Hz
Exposure duration:
30 min
|
|
| Frequency | 50 Hz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | 30 min |
| Exposure source |
|
|---|---|
| Setup | electromagnet consisting of a C-shaped steel bar with four blocks of exposure coils; a non metallic dorsal skinfold chamber was implanted in the animal; animals placed in an acrylic resin tube of 26 mm (inner diameter) which was fixed onto a non metallic microscope stage and then placed within the electromagnet |
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 3 mT | unspecified | measured | - | - |
| Frequency | 50 Hz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | 30 min |
| Exposure source |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 10 mT | unspecified | measured | - | - |
| Frequency | 50 Hz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | 30 min |
| Additional info | Exposure and sham exposure groups consisted of 10 to 11 animals each. |
| Exposure source |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 30 mT | unspecified | measured | - | - |
Following exposure, the mean velocity of free flowing leukocytes in the center stream of venules showed no distinct changes. However, at a flux density of 30 mT the number of adherent leukocytes increased significantly following exposure; no significant differences in adherent cell numbers were found in the 3 mT and 10 mT exposed mice or sham exposed controls comparing pre- and post-exposure periods.
These data demonstrated that high magnetic flux densities of extremely low frequency electromagnetic field had an effect on leukocyte-endothelium interactions. The results indicate that a threshold level for this phenomenon exists in the range of 10-30 mT under these experimental conditions.
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