Study type: Medical/biological study (experimental study)

Subcutaneous Arteriolar Vasomotion Changes During and After ELF-EMF Exposure in Mice in Vivo. med./bio.

Published in: Environmentalist 2005; 25 (2-4): 93-101

Aim of study (acc. to author)

The question whether the acute (for 10 minutes) exposure to extremely low frequency electromagnetic field at three different frequencies (10, 16, and 50 Hz) can affect the microcirculation in mice should be investigated in this in vivo study.

Background/further details

Conscious (not anaesthetized) 34 male, 8-12 week old male mice were used in this experiment.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 10 Hz
Exposure duration: continuous for 10 min
Exposure 2: 16 Hz
Exposure duration: continuous for 10 min
Exposure 3: 50 Hz
Exposure duration: continuous for 10 min

Exposure 1

Main characteristics
Frequency 10 Hz
Type
Waveform
  • unspecified
Exposure duration continuous for 10 min
Exposure setup
Exposure source
Setup An acrylic restrainer with experimental animal in prone position was placed on the observing stage of a fluorescence microscope. The electromagnet was placed on a mobile basement which was positioned over the acrylic observation stage of the microscope (160 x 160 x 5 mm). The animals were located in the center of maximal EMF flux density.
Additional info The experiments consisted of three observation periods , the first 3 min consisted of a pre-exposure period, followed by 10 min of sham or real exposure period and a post exposure period of 20 min. The steel bar of the exposure device was covered by a silica iron laminated alloy to prevent heat transfer due to eddy currents.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 28 mT effective value measured - -

Exposure 2

Main characteristics
Frequency 16 Hz
Type
Waveform
  • unspecified
Exposure duration continuous for 10 min
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 28 mT effective value measured - -

Exposure 3

Main characteristics
Frequency 50 Hz
Type
Waveform
  • unspecified
Exposure duration continuous for 10 min
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 28 mT effective value measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • before exposure
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

During and after the electromagnetic field exposure arteriole diameters increased significantly compared with the pre-exposure period. The differences were larger during post-exposure period and in the 16 Hz exposure group.
These results suggest a vasodilative effect of electromagnetic fields.

Study character:

Study funded by

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