Study type: Medical/biological study (experimental study)

Pulsed electromagnetic fields induce peripheral nerve regeneration and endplate enzymatic changes. med./bio.

Published in: Bioelectromagnetics 2005; 26 (1): 20-27

Aim of study (acc. to author)

To investigate the effects of pulsed electromagnetic fields on regenerative capabillity of the peripheral nervous system in rats.

Background/further details

Direct nerve fibre regeneration as well as biochemical changes should be investigated by microscopy and enzymatic assays, respectively.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 15 Hz
Modulation type: pulsed
Exposure duration: repeated daily exposure, 6 h/day for 4 weeks

Exposure 1

Main characteristics
Frequency 15 Hz
Type
Waveform
Exposure duration repeated daily exposure, 6 h/day for 4 weeks
Modulation
Modulation type pulsed
Additional info

the duty cycle of the magnetic signal consisted of 20 sawtooth pulses with a peak to peak separation between each pulse of 200 µs; these pulses were delivered for 5 ms followed by a refractory period of 62 ms

Exposure setup
Exposure source
Chamber Animal cages
Setup Coils were placed above and along the total length of the animal cages (animals were not restrained).
Additional info Animals were divided into the A, AS, T, TS, P and PS groups (n=8 each). AS, TS and PS were exposed whereas A, T and P were used as control.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 900 µT - measured - to 1800 µT

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Pulsed electromagnetic field application leads to a statistically significant increase of the regeneration index as well as an increase in the acivities of the enzymes acetyl cholinesterase and NAD specific isocitrate dehydrogenase.

Study character:

Study funded by

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