An electrophysiological investigation of the influence of radiofrequency electromagnetic fields on brain functions in Lurcher mutant mice, which represent a model of neurodegenerative disease, and on healthy control mice.
Exposure duration: see add. information
All experiments were performed under urethane anaesthesia.
|Exposure duration||see add. information|
|Setup||The EMF was directed by a waveguide with an orifice area of 600 cm² to the space where the animals were placed (modified stereotaxic frame).|
|Sham exposure||A sham exposure was conducted.|
|Additional info||Spontaneous electrocorticogram was measured as 2 min segments from continuously recorded activity either with or without RF EMF exposure. Recording time for each animal was approx. 40 min. The actual duration of exposure is not clear.|
Spontaneous electrocorticogram evaluation showed a distinct shift to lower frequency components but clear effect has been found only in wild type mice whereas in Lurcher mutant mice only gentle differences between frequency spectra were revealed. Measurement of hippocampal rhythmicity showed gentle changes with increase of higher frequencies (i.e. opposite effect than in cortex) and changes in theta oscillations registered from a dentate gyrus and CA1 area in both types of animals (wild type and mutant).
These data support the idea about possible influencing the central nervous system by radiofrequency electromagnetic field exposure.