To study the acute effects of local application of a static magnetic field to neck or pelvic region under pharmacologically modulated blood pressure; norepinephrine-induced hypertension as well as nicardipine (calcium channel blocker)-induced hypotension in conscious rabbits
|Setup||the rabbit was placed in a plastic cylinder holder (50 cm long, 16 cm inner diameter) which was placed into the pair of electromagnets. One electromagnet was located over the neck of the rabbit while the other one over the pelvis region.|
Neck exposure significantly attenuated the pharmacologically induced vasoconstriction or vasodilation, and subsequently suppressed the increase or decrease in blood pressure compared with sham exposure. In contrast, pelvis exposure did not significantly antagonized norepinephrine-elevated blood pressure or nicardipine-reduced blood pressure.
The neck exposure had a biphasic and restorative effect on vascular tone and blood pressure acting to normalize the tone and blood pressure. The neck exposure caused a significant increase in baroreflex sensitivity in norepinephrine-elevated blood pressure compared with sham exposure.
The buffering effects of the static magnetic field on increased hemodynamic differences between norepinephrine-induced high vascular tone and nicardipine-induced low vascular tone might be, in part, dependent on baroreflex pathways, which could modulate norepinephrine-mediated response in conjunction with Ca2+ dynamics.