Study type: Medical/biological study (experimental study)

Acceleration of the development of benzopyrene-induced skin cancer in mice by microwave radiation med./bio.

By: Szudzinski A, Pietraszek A, Janiak M, Wrembel J, Kalczak M, Szmigielski S
Published in: Arch Dermatol Res 1982; 274 (3-4): 303-312
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Aim of study (acc. to author)

To evaluate the effect of long-term low-level microwave radiation on the development of skin cancer in mice chronically exposed to 3,4-benzopyrene.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Exposure duration: 2 h/day, 6 days/week for 1, 2, 3, or 6 months

General information

Skin cancer induction was preformed by shaving 1 cm² skin surface on the back of a mouse and droping 0.01 ml of benzopyrene solution.

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Waveform
Charakteristic
Exposure duration 2 h/day, 6 days/week for 1, 2, 3, or 6 months
Modulation
Modulation type unspecified
Exposure setup
Exposure source
Chamber Anechoic chamber maintained at 22°C and 65 % humidity.
Setup Mice were restrained in a plastic cage, 10 mice per cage, in the chamber.
Additional info Control animals were exposed to benzopyrene treatment for 6 months.
Parameters
Measurand Value Type Method Mass Remarks
power density 50 W/m² unspecified measured - 2 mW/g corresponding SAR value.
power density 150 W/m² unspecified measured - 6 mW/g corresponding SAR value.
power density 100 W/m² unspecified measured - 4 mW/g corresponding SAR value.
Additional parameter details

SAR values were tested in murine cadavers by measuring the increase of body temperature in relation to field power density. The SAR were found for the respective power densities by extrapolation.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

The results clearly indicate that microwave irradiation may, at least in this experimental system, stimulate the development of chemically induced skin cancer and in shortening of life span of the tumour-bearing hosts. The effect seemed to be dose-dependent since subthermal doses (15 mW/cm²) and longer expositions (3 months) were more efficient as compared to athermal doses (5 mW/cm²) and shorter preirradiations.

Study character:

Study funded by

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