To investigate the effects of a 60 Hz magnetic field exposure in the SENCAR mouse model.
DMBA and TPA were used for the chemical induction of skin tumor. Furthermore the activity of natural killer cells (NK cells) in spleen and blood were examined. A total of 160 animals were used in this study (5 groups/32 animals each). All animals received a single subcarcinogenic administration of DMBA (10 nmol). Group A (sham-exposed) and group B (daily exposed) were not treated with TPA, whereas group C (sham-exposed) and group D (exposed five days/week) were applicated once weekly with 1 µg TPA. Group E serves as a positive control, without being exposed but treated with 2 µg TPA twice weekly.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
60 Hz
Exposure duration:
6 h/day, 5 days/week for 21 weeks
|
|
| Frequency | 60 Hz |
|---|---|
| Type | |
| Exposure duration | 6 h/day, 5 days/week for 21 weeks |
| Exposure source |
|
|---|---|
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 2 mT | - | - | - | - |
Group A and B were used to determine whether the applied magnetic field could act like a classical tumor promoter. No papilloma development could be detected in these groups. Also no significant effect between these groups could be observed concerning NK cell activity.
Group C and D were used to determine if the applied magnetic field (together with the TPA application) could act as a tumor co-promoter. However, no statistically significant difference in tumor development could be found between these groups. The only effect demonstrated by this study was a significantly greater proportion of mice with enlarged spleens and increased number of mononucleated spleen cells in group D compared with the sham exposed group C.
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