Study type: Medical/biological study (experimental study)

A 60 Hz magnetic field does not affect the incidence of squamous cell carcinomas in SENCAR mice. med./bio.

Published in: Bioelectromagnetics 2003; 24 (2): 75-81

Aim of study (acc. to author)

To investigate possible promoting or co-promoting effects of a 60 Hz magnetic field exposure in the SENCAR mouse model.

Background/further details

DMBA and PMA (phorbol myristate acetate) were used for the chemical induction of skin tumors. A total of 96 mice were used in this study (2 groups/48 animals each). One group served as a sham-exposed control. Tumor development was initiated with a single dose of DMBA (10 nmol) and mice were treated with PMA (phorbol myristate acetate, 3 µg) once a week thereafter. First administration of PMA and the magnetic field exposure started one week after the initial DMBA treatment. PMA treatment was continued for 23 weeks and the magnetic field exposure for additional 29 weeks (i.e. a total of 52 weeks of exposure or sham-exposure, respectively).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: 6 h/day, 5 day/week for 52 weeks

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Exposure duration 6 h/day, 5 day/week for 52 weeks
Exposure setup
Exposure source
Chamber two Quad/4x Exposure chambers
Additional info Each chamber held 4 exposure cages constructed from 6 mm plastic, each cage 39.4 cm x 26.0 x 14.9 cm further subdivided into 4 exposure suits, each suit 9.88 cm x 26 cm x 14.9 cm capable of holding 3 mice.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 2 mT mean measured unspecified -
magnetic flux density 235 nT mean measured unspecified 0.140 µT; with the coils inactive in the chambers

Reference articles

  • McLean JR et al. (1997): The effect of 60 Hz magnetic fields on co-promotion of chemically induced skin tumors on SENCAR mice: a discussion of three studies.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

No differences were found between the two groups. Neither the development of papillomas nor squamous cell carcinomas were influenced under the experimental conditions of this study.

Study character:

Study funded by

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