To investigate whether a transient-producing intermittent magnetic field exerts a promoting effect on DMBA-induced mammary tumor development in rat.
A total of 180 animals were used in this study, divided into 3 groups: Group A) 60 rats, 0.25 mT MF exposure, DMBA-treated. Group B) 60 rats, 0.5 mT MF exposure, DMBA-treated. Group C) 60 animals, no MF exposure, DMBA-treated.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
50 Hz
Exposure duration:
intermittent, 15s on/off, 19 h/day (weekdays), 21 h /day (weekends), for 21 weeks
|
|
|
Exposure 2:
50 Hz
Exposure duration:
intermittent, 15s on/off, 19 h/day (weekdays), 21 h /day (weekends), for 21 weeks
|
|
| Frequency | 50 Hz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | intermittent, 15s on/off, 19 h/day (weekdays), 21 h /day (weekends), for 21 weeks |
| Exposure source |
|
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 250 µT | unspecified | measured | - | - |
| Frequency | 50 Hz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | intermittent, 15s on/off, 19 h/day (weekdays), 21 h /day (weekends), for 21 weeks |
| Exposure source |
|
|---|
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 500 µT | unspecified | measured | - | - |
A single application of 7 mg DMBA/animal was given to rats 52 days of age and MF exposure were initiated 7 days thereafter and ongoing for 21 weeks.
No statistical difference was found either for tumor-bearing animals or for the total number of tumors. Animals exposed to 0.25 mT exhibited a slightly larger total tumor weight and tumor volume, but these findings were not statistically significant.
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