Study type: Medical/biological study (experimental study)

Lack of effect of a 60 Hz magnetic field on biomarkers of tumor promotion in the skin of SENCAR mice med./bio.

By: DiGiovanni J, Johnston DA, Rupp T, Sasser LB, Anderson LE, Morris JE, Miller DL, Kavet R, Walborg Jr EF
Published in: Carcinogenesis 1999; 20 (4): 685-689
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Aim of study (acc. to author)

To investigate a possible co-promoting effect of an extremely low frequency magnetic field exposure of chemical induced skin tumorigenesis of mice.

Background/further details

A pilot study including 224 animals was conducted to select propper doses of TPA and to identify environmental effects on biomarkers.
The primary study includes a total of 192 animals, divided into 8 groups (24 animals each). Groups were treated either with none TPA or with doses of 0.85 nmol, 1.7 nmol, or 3.4 nmol TPA respectively. All mice were initiated by a single application of 10 nmol DMBA and TPA was administrated twice a week. The biomakers (i.e. epidermal thickness, enzyme activity and so on) were evaluated after 1, 2 and 5 weeks of TPA- induced promotion.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: 6 h/day, 5 days/week, up to 5 weeks

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Waveform
Exposure duration 6 h/day, 5 days/week, up to 5 weeks
Exposure setup
Exposure source
  • not specified
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 2 mT - - - -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No consistent, statistically significant promotional or co-promotional effect of the magnetic field could be demonstrated within the methodological limits and exposure parameters employed.

Study character:

Study funded by

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