Study type: Medical/biological study (experimental study)

Magnetic field conditioned taste aversion in rats. med./bio.

Published in: Physiol Behav 1998; 63 (4): 683-688

Aim of study (acc. to author)

The taste aversion procedure was used to examine the effect of exposure to a high magnetic field.

Background/further details

Conditioned taste aversion is a classic conditioning procedure used to identify noxious stimuli. When a rat is given a taste solution (the conditioned stimulus) followed by an unpleasant experience (the unconditioned stimulus), the rat will avoid consumption of the conditioned stimulus in future presentations.
A solution consisting of glucose and saccharin was used as the conditioned stimulus and a 9.4-T magnet served as the unconditioned stimulus. In Experiment 1, all animals received a 10 min presentation of the glucose + saccharin solution followed by either a 30 min exposure to the magnetic field. Experiment 2 employed the same unconditioned stimulus-conditioned stimulus protocol for 3 consecutive days of conditioning.

Endpoint

Exposure

Exposure Parameters
Exposure 1:
Exposure duration: 30 min
Exposure 2:
Exposure duration: 30 min/day for 3 consecutive days

Exposure 1

Main characteristics
Frequency
Type
Polarization
  • elliptical
Exposure duration 30 min
Additional info Experiment 1. Vertically oriented magnetic field.
Exposure setup
Exposure source
Chamber plexiglass tube (5cm diameter) to restrain rats
Setup The plexiglass tube containing the rat was inserted into the magnet
Additional info The tube had a cone shape in which the head of the animal was inserted. The core had a 1 mm hole for breathing purpose. A plug which accommodated the tail was inserted into the bottom of the tube to restrain movement. The control rats remained in their home cages
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 9.4 T unspecified unspecified - -

Exposure 2

Main characteristics
Frequency
Type
Exposure duration 30 min/day for 3 consecutive days
Additional info Experiment 2
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 9.4 T unspecified unspecified - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

In the first experiment the exposed magnet group showed a taste aversion on the first day of preference testing.
In the second experiment the magnet group showed a taste aversion for the post-exposure days 1-8. There was no difference between the sham exposure and control groups in either experiment.
The data clearly revealed that the animals associated the glucose + saccharin solution with the experience of being exposed to the high magnetic field and avoided the solution in subsequent presentations.

Study character:

Study funded by

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