Study type: Medical/biological study (experimental study)

The influence of electromagnetic field irradiated by high-voltage transmission lines on properties of cells. med./bio.

Published in: No authors listed, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference, Shanghai, China, 2005 IEEE, 2005: 2997-3000, ISBN 9780780387416

Aim of study (acc. to author)

To study the influence of the electromagnetic fields emitted by high-voltage lines on the signal transduction in the spleen cells of rats.

Background/further details

32 rats were divided in one experimental and one control group. Spleen cells of exposed rats were partly stimulated with IL-2 (after exposure; IL-2 can active the JAK-STAT signal transduction pathway).
The JAK/STAT signal transduction pathway plays an important role in regulating gene expression and cellular activation.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous for 400 days

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration continuous for 400 days
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 9 µT unspecified measured - to 10 µT
electric field strength 4 kV/m unspecified measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data showed that the phosphor-STAT3 expression was remarkably up-regulated in spleen cells stimulated by IL-2 and the electromagnetic field, whereas the phosphor-STAT3 expression was slightly up-regulated in these spleen cells stimulated only by IL-2 (in the control group). The findings indicate that the electromagnetic fields of high-voltage lines accelerate the process of phosphorylation of STAT3 activated by IL-2, thus it activate also the JAK-STAT signal transduction pathway.

Study character:

Study funded by

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