To study the influence of the electromagnetic fields emitted by high-voltage lines on the signal transduction in the spleen cells of rats.
32 rats were divided in one experimental and one control group. Spleen cells of exposed rats were partly stimulated with IL-2 (after exposure; IL-2 can active the JAK-STAT signal transduction pathway).
The JAK/STAT signal transduction pathway plays an important role in regulating gene expression and cellular activation.
Exposure duration: continuous for 400 days
|Exposure duration||continuous for 400 days|
|magnetic flux density||9 µT||unspecified||measured||-||to 10 µT|
|electric field strength||4 kV/m||unspecified||measured||-||-|
The data showed that the phosphor-STAT3 expression was remarkably up-regulated in spleen cells stimulated by IL-2 and the electromagnetic field, whereas the phosphor-STAT3 expression was slightly up-regulated in these spleen cells stimulated only by IL-2 (in the control group). The findings indicate that the electromagnetic fields of high-voltage lines accelerate the process of phosphorylation of STAT3 activated by IL-2, thus it activate also the JAK-STAT signal transduction pathway.