Study type: Medical/biological study (experimental study)

Microglial activation as a measure of stress in mouse brains exposed acutely (60 minutes) and long-term (2 years) to mobile telephone radiofrequency fields. med./bio.

Published in: Pathology 2010; 42 (2): 151-154

Aim of study (acc. to author)

To study whether acute (60 min) or long-term (five days per week, 104 weeks) exposure of the mouse brain to mobile phone radiofrequency fields produces activation of microglia, which normally respond rapidly to any change in their microenvironment.

Background/further details

Microglia is considered as a specialised form in the central nervous system. In response to a variety of insults, microglia adopts an activated phenotype. Microglia activation plays a pivotal role in the initiation and progression of several neurodegenerative diseases.
30 mice were divided into three groups: 1) exposure group (n=10; remark of EMF-Portal editor: number of animals (distribution) in the acute and long-term exposure group unclear), 2) sham exposure group (n=10) and 3) cage control (n=10). Positive controls were also included (stab wound treatment).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Modulation type: pulsed
Exposure duration: continuous for 60 min
Exposure 2: 900 MHz
Modulation type: pulsed
Exposure duration: continuous for 5 days/week for 104 weeks
long-term exposure

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Charakteristic
Exposure duration continuous for 60 min
Additional info acute exposure
Modulation
Modulation type pulsed
Pulse width 0.6 ms
Repetition frequency 217 Hz
Additional info

GMS like field

Exposure setup
Exposure source
Setup mice in perspex tubes arranged radially around the dipole antenna
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 4 W/kg - - whole body -

Exposure 2

Main characteristics
Frequency 900 MHz
Type
Charakteristic
Exposure duration continuous for 5 days/week for 104 weeks
Additional info long-term exposure
Modulation
Modulation type pulsed
Pulse width 0.6 ms
Repetition frequency 217 Hz
Additional info

GMS like field

Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 4 W/kg - - whole body -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

There was no increase in microglial Iba1 expression in brains of short or long-term exposed mice compared to the controls (sham exposed or cage control), while substantial microglial activation occurred in damaged positive control neural tissue.
The authors conclude that an acute or longer duration exposure of murine brains to mobile phone radiofrequency electromagnetic fields did not produce any microglial activation detectable by Iba1 immunostaining.

Study character:

Study funded by

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