Study type: Medical/biological study (experimental study)

Glucose homeostasis in rats exposed to magnetic fields. med./bio.

Published in: Invest Radiol 1991; 26 (12): 1095-1100

Aim of study (acc. to author)

To test whether magnetic fields generate disturbances in the glucose homeostasis of rats.

Background/further details

The experiment was carried out on male rats aged 4 months. Animals were divided into 1.) ten experimental groups exposed to a magnetic field of 10 mT, 2.) 10 experimental groups exposed to a magnetic field of 10 mT and 3.) 10 control groups. Each group contained 10 animals. Rats were exposed for 1 hour a day for 10 days. Every day, one group of every experimental condition was decapitated and blood was collected.

Endpoint

Exposure

Exposure Parameters
Exposure 1:
Exposure duration: 1 h/day for up to 10 days
Exposure 2:
Exposure duration: 1 h/day for up to 10 days

Exposure 1

Main characteristics
Frequency
Type
Exposure duration 1 h/day for up to 10 days
Exposure setup
Exposure source
Setup poles of the magnet 0.22 m apart; rats were placed between the magnetic poles in a well ventilated glass container
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT - - - -

Exposure 2

Main characteristics
Frequency
Type
Exposure duration 1 h/day for up to 10 days
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 10 mT - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • before exposure
  • after exposure

Main outcome of study (acc. to author)

During the first 3 days, the plasma level of glucose increased significantly in rats exposed to a 10-3 tesla magnetic field compared to control animals. At the 7th day of exposure the level of glucagon was significantly higher in both exposure groups compared to the control group. The level of insulin decreased after 5 days and was significanty lowered after 10 days in the exposed groups compared to the control group. In the exposed groups, the contents of growth hormone and thyroid-stimulating hormone increased significant, as well as the levels of triiodothyronine and thyroxine between the 3rd and the 7th day as compared to the control group. Between the 2nd and the 4th day the level of cortisol was significantly increased in both exposure groups in comparison to the control group.
The authors conclude, that the results might implicate a temporarily diabetic-like response in rats exposed to the magnetic field.

Study character:

Study funded by

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