研究のタイプ: 医学/生物学の研究 (experimental study)

[磁界ばく露したラットにおけるグルコース恒常性] med./bio.

Glucose homeostasis in rats exposed to magnetic fields.

掲載誌: Invest Radiol 1991; 26 (12): 1095-1100

この研究は、磁気共鳴画像法MRI)に付随する潜在的な悪影響として先行研究で報告がある血中ホルモンレベルへの影響を調べた。ラットに、1 mTおよび10 mTの一様な定常磁界への毎日1時間のばく露を10日間継続した。その結果、対照群に比べ、ばく露群では、血糖値がわずかに増加し、インスリンの放出が減少し、グルカゴン含量が増加した;成長ホルモン甲状腺刺激ホルモンのレベルの増加によって示されるように、脳下垂体-視床下部系の効率が変化した;甲状腺ホルモンであるトリヨードチロニンとチロキシンの含有量は、ばく露の3日目からと7日目までの間で高かった;コルチゾールレベルの増加も観察された、と報告している。

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研究目的(著者による)

To test whether magnetic fields generate disturbances in the glucose homeostasis of rats.

詳細情報

The experiment was carried out on male rats aged 4 months. Animals were divided into 1.) ten experimental groups exposed to a magnetic field of 10 mT, 2.) 10 experimental groups exposed to a magnetic field of 10 mT and 3.) 10 control groups. Each group contained 10 animals. Rats were exposed for 1 hour a day for 10 days. Every day, one group of every experimental condition was decapitated and blood was collected.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1:
  • DC/static
ばく露時間: 1 h/day for up to 10 days
ばく露2:
  • DC/static
ばく露時間: 1 h/day for up to 10 days

ばく露1

主たる特性
周波数
  • DC/static
タイプ
  • magnetic field
ばく露時間 1 h/day for up to 10 days
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 poles of the magnet 0.22 m apart; rats were placed between the magnetic poles in a well ventilated glass container
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 1 mT - - - -

ばく露2

主たる特性
周波数
  • DC/static
タイプ
  • magnetic field
ばく露時間 1 h/day for up to 10 days
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 10 mT - - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露前
  • ばく露後

研究の主なアウトカム(著者による)

During the first 3 days, the plasma level of glucose increased significantly in rats exposed to a 10-3 tesla magnetic field compared to control animals. At the 7th day of exposure the level of glucagon was significantly higher in both exposure groups compared to the control group. The level of insulin decreased after 5 days and was significanty lowered after 10 days in the exposed groups compared to the control group. In the exposed groups, the contents of growth hormone and thyroid-stimulating hormone increased significant, as well as the levels of triiodothyronine and thyroxine between the 3rd and the 7th day as compared to the control group. Between the 2nd and the 4th day the level of cortisol was significantly increased in both exposure groups in comparison to the control group.
The authors conclude, that the results might implicate a temporarily diabetic-like response in rats exposed to the magnetic field.

研究の種別:

研究助成

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