Study type: Medical/biological study (experimental study)

Effects of exposure to DAMPS and GSM signals on ornithine decarboxylase (ODC) activity: II. SH-SY5Y human neuroblastoma cells. med./bio.

Published in: Int J Radiat Biol 2009; 85 (6): 519-522

Aim of study (acc. to author)

To investigate the effects of microwave exposure on the enzyme activity of ornithine decarboxylase and to extend a previous confirmation study of the same authors (Billaudel et al. 2009) to human neuroblastoma cells.

Background/further details

In previous studies, an increase in ornithine decarboxylase enzyme activity was found in L929 murine fibroblast cells after exposure to a digital cellular telephone signal (see "related articles"). This result was not confirmed by several other studies, including the paper of Billaudel et al. 2009.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 835 MHz
Modulation type: pulsed
Exposure duration: continuous for 8 h or 24 h
Exposure 2: 1,800 MHz
Modulation type: pulsed
Exposure duration: continuous for 8 h or 24 h

Exposure 1

Main characteristics
Frequency 835 MHz
Type
Exposure duration continuous for 8 h or 24 h
Modulation
Modulation type pulsed
Repetition frequency 50 Hz
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.99 W/kg - measured - during 8 h exposure
SAR 2.48 W/kg - measured - during 8 h exposure
SAR 1 W/kg - measured - during 24 h exposure
SAR 2.49 W/kg - measured - during 24 h exposure

Exposure 2

Main characteristics
Frequency 1,800 MHz
Type
Exposure duration continuous for 8 h or 24 h
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.99 W/kg - measured - during the 8 h exposure
SAR 2.49 W/kg - measured - during the 8 h exposure
SAR 1 W/kg - measured - during the 24 h exposure
SAR 2.51 W/kg - measured - during the 24 h exposure

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The results showed that, irrespective of the signal used (D-AMPS-835 or GSM-1800) and exposure conditions (duration and SAR value), human SH-SY5Y neuroblastoma cells did not exhibit any alteration in ornithine decarboxylase enzyme activity. In conclusion, this work did not show a significant effect of mobile phone radiofrequency exposure on ornithine decarboxylase enzyme activity in neuroblastoma cells (SH-SY5Y).

Study character:

Study funded by

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