Study type: Epidemiological study (observational study)

Familial, environmental, and occupational risk factors in development of amyotrophic lateral sclerosis. epidem.

Published in: N Am J Med Sci 2012; 4 (8): 350-355

Aim of study (acc. to author)

A case-control study was conducted in India to investigate familial, environmental, and occupational risk factors in development of amyotrophic lateral sclerosis.

Further details

Following electromagnetic field-related aspects were studied: working under magnetic field for more than 10 years and electrical injury. Furthermore, family history of disease, smoking, occupation, living place (rural/urban), source of drinking water, exposure to insecticides, pesticides, heavy metals (iron), solvents, and chemicals were investigated.

Endpoint/type of risk estimation

Type of risk estimation: (odds ratio (OR))

Exposure

Assessment

Population

Case group

Control group

Study size

Cases Controls
Eligible 110 240
Statistical analysis method:

Conclusion (acc. to author)

A significant increased risk for developing amyotrophic lateral sclerosis was found for electrical injury (OR 6.2, CI 1.75-21.98), based on 8 cases and 3 controls. Since no case has been found with history of working under magnetic field, this factor could not be analyzed.
Significant associations were observed for rural livings (OR 1.99, CI 1.02-3.88), smoking (OR 1.88, CI 1.19-2.96), insecticides and pesticides exposures (OR 1.61, CI 1.27-1.99).

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