Study type: Epidemiological study (observational study)

Prospective study of occupation and amyotrophic lateral sclerosis mortality epidem.

Published in: Am J Epidemiol 2005; 162 (12): 1146-1152

Aim of study (acc. to author)

The relation between occupation and amyotrophic lateral sclerosis mortality was investigated in a prospective cohort study in the USA.

Further details

Occupations were categorized according to the 1980 Bureau of the Census occupational titles and were assigned to one of 13 broad occupational groups.

Endpoint/type of risk estimation

Type of risk estimation:




Study size

Type Value
Total 1,184,561
Statistical analysis method: (adjustment: )

Results (acc. to author)

Overall, 507 deaths from amyotrophic lateral sclerosis were observed during 4,913,369 person-years among men and 430 deaths during 7,081,569 person-years among women.
No association between death from amyotrophic lateral sclerosis and the occupations of electrician, welder, or farmer, each of which has been associated with amyotrophic lateral sclerosis in previous studies, was observed in this prospective study. Among men, increased amyotrophic lateral sclerosis mortality was found for programmers (RR 4.55, CI 1.46-14.2) and laboratory technicians (RR 1.96, CI 1.04-3.66). Among women, elevated amyotrophic lateral sclerosis mortality was observed for machine assemblers (RR 2.81, CI 1.05-7.53) and a marginally significant increase was found for nurses (RR 1.40, CI 0.96-2.04). These results were based on a small number of cases in each occupational category, however, and should be interpreted cautiously.

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