Study type: Epidemiological study

Amyotrophic Lateral Sclerosis and Occupational Exposures: A Systematic Literature Review and Meta-Analyses. epidem.

Published in: Int J Environ Res Public Health 2018; 15 (11)

Aim of study (acc. to author)

The association between the risk of amyotrophic lateral sclerosis (ALS) and occupational exposure to extremely low-frequency magnetic fields or work with electricity as well as other occupational risk factors (e.g. lead, chemicals) was evaluated in a meta-analysis.

Further details

Following 17 studies were included in the meta-analysis: Feychting et al. (2003), Fischer et al. (2015), Gunnarsson et al. (1991), Hakansson et al. (2003), Huss et al. (2015), Johansen et al. (1998), Johansen (2000), Noonan et al. (2002), Park et al. (2005), Parlett et al. (2011), Pedersen et al. (2017), Savitz et al. (1988a), Savitz et al. (1988b), Sorahan et al. (2007), Sorahan et al. (2014), Vergara et al. (2015) and Weißkopf et al. (2015).

Endpoint/type of risk estimation

Exposure

Assessment

Population

Statistical analysis method:

Conclusion (acc. to author)

Overall, the studies showed a slightly increased risk of amyotrophic lateral sclerosis for workers exposed to extremely low frequency magnetic fields (RR 1.23, CI 1.04-1.45) and for workers in electrical occupations (RR 1.16, CI 1.00-1.35), An analysis over the time period 1991-2015 in which the results of earlier studies were gradually cumulated showed a successive reduction of the risk. For the period 1991–2005, a higher risk (RR 1.33, CI 1.11-1.58) was found compared to the period 2006–2015 (RR 1.18, CI 1.07-1.31).
The authors concluded that the results suggest a possible association between amyotrophic lateral sclerosis and occupational exposure to extremely low frequency magnetic fields.

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