Study type: Medical/biological study (experimental study)

Extremely low-frequency magnetic field induces manganese accumulation in brain, kidney and liver of rats. med./bio.

Published in: Toxicol Ind Health 2015; 31 (6): 576-580

Aim of study (acc. to author)

To examine the effects of exposure to an extremely low frequency magnetic field on the accumulation of manganese in the kidney, liver and brain of rats.

Background/further details

To develop neurotoxicity prevention strategies, the effects of metals (for example manganese) on organisms exposed to extremely low frequency magnetic fields should be examined. Therefore, rats were divided into 8 groups (n=5 per group) and received different amounts of manganese every second day for 45 days: 1.) no manganese, 2.) 3.75 mg manganese per kg body weight, 3.) 15 mg manganese per kg body weight and 4.) 60 mg manganese per kg body weight. The rats were exposed or unexposed.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 4 hours per day on 5 days/week during 45 days

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration 4 hours per day on 5 days/week during 45 days
Exposure setup
Exposure source
Chamber rats were housed individually in stainless steel methacrylate cages
Setup magnetic field was generated by two pairs of Helmholtz coils (70 cm in diameter) in a Faraday cage (130 x 65 x 80 cm); magnet was constructed by winding 125 turns of insulated soft copper wire with a diameter of 1.5 mm; coils were vertically placed facing one another; distance between coils: 47 cm
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.5 mT - measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:

Main outcome of study (acc. to author)

In exposed groups, the amount of manganese was significantly higher than in the unexposed groups. Only in the kidney, no significant differences were found between the exposed and the not exposed group which received no manganese.
The data indicate that exposure to an extremely low frequency magnetic field could lead to an accumulation of manganese in the kidney, liver and brain of rats.

Study character:

Study funded by

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