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To examine the effects of exposure to an extremely low frequency magnetic field on the accumulation of manganese in the kidney, liver and brain of rats.
To develop neurotoxicity prevention strategies, the effects of metals (for example manganese) on organisms exposed to extremely low frequency magnetic fields should be examined. Therefore, rats were divided into 8 groups (n=5 per group) and received different amounts of manganese every second day for 45 days: 1.) no manganese, 2.) 3.75 mg manganese per kg body weight, 3.) 15 mg manganese per kg body weight and 4.) 60 mg manganese per kg body weight. The rats were exposed or unexposed.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
50 Hz
ばく露時間:
4 hours per day on 5 days/week during 45 days
|
|
| 周波数 | 50 Hz |
|---|---|
| タイプ |
|
| ばく露時間 | 4 hours per day on 5 days/week during 45 days |
| ばく露の発生源／構造 | |
|---|---|
| チャンバの詳細 | rats were housed individually in stainless steel methacrylate cages |
| ばく露装置の詳細 | magnetic field was generated by two pairs of Helmholtz coils (70 cm in diameter) in a Faraday cage (130 x 65 x 80 cm); magnet was constructed by winding 125 turns of insulated soft copper wire with a diameter of 1.5 mm; coils were vertically placed facing one another; distance between coils: 47 cm |
| 測定量 | 値 | 種別 | Method | Mass | 備考 |
|---|---|---|---|---|---|
| 磁束密度 | 1.5 mT | - | 測定値 | - | - |
In exposed groups, the amount of manganese was significantly higher than in the unexposed groups. Only in the kidney, no significant differences were found between the exposed and the not exposed group which received no manganese.
The data indicate that exposure to an extremely low frequency magnetic field could lead to an accumulation of manganese in the kidney, liver and brain of rats.
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