P-selectin is a protein which functions as a cell adhesion molecule on the surfaces of endothelial cells and has a functional role in metastasis of tumor.
Rats were divided into four groups: 1.) control group (n=5), 2.) weekly rectally carcinogen administration (2 mg N-Methyl-N-Nitrosurea dissolved in 0.2 ml isotonic solution, for 10 weeks) (n=7), 3.) magnetic field exposure (n=9) and 4.) weekly rectally carcinogen administration (2 mg N-Methyl-N- Nitrosurea dissolved in 0.2 ml isotonic solution, for 10 weeks) + magnetic field exposure (n=7). The control group and the magnetic field exposure group were treated with saline solution without carcinogen in the same way.
Exposure duration: 6 hours/day for 8 month
|Chamber||rats were housed in a polycarbonate cage|
|Setup||12 copper solenoid coils (560 turns, resepctively) were serially connected, cores of the coils were filled with soft iron rods and tightened to increase the magnetic flux intensity, coils were vertically placed and the cages were held 1.2 cm above the coils to diminish vibration, 1 cm thick wooden plates were placed between the coils and cages to avoid heating, coils were connected to the 220 V 50 Hz sinusoidal city electric systems|
|magnetic flux density||5 mT||-||measured||-||-|
No significant differences in the protein expression level of P-selectin were observed between the groups as well as no differences regarding food consumption.
The authors conclude that additional studies are required to verify the results.