Study type: Medical/biological study (experimental study)

Variable E-cadherin expression in a MNU-induced colon tumor model in rats which exposed with 50 Hz frequency sinusoidal magnetic field. med./bio.

Published in: Tohoku J Exp Med 2002; 198 (4): 245-249

Aim of study (acc. to author)

The effects of a chronic whole body exposure of rats to a 50 Hz magnetic field on the E-cadherin expression in colon tumors should be investigated.

Background/further details

E-cadherin is a protein in the cell membrane with importance for cell adhesion. A reduced expression of E-cadherin is related to an increased metastasis formation of tumor cells. The formation of colon tumors was provoked by rectal adminstration of N-methyl-N-nitrosourea. 30 rats were divided into the following four groups: 1) N-methyl-N-nitrosourea alone (n=10), 2) N-methyl-N-nitrosourea and magnetic field exposure (n=10), 3) magnetic field exposure alone (n=5), 4) control (n=5).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 6 h/day for 8 months

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 6 h/day for 8 months
Exposure setup
Exposure source
Chamber the rats were housed in fives per polycarbonate cage
Setup twelve serially connected solenoids with an iron core and 860 turns of copper wire each
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 5 mT - measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No statistically significant differences in the expression rate of E-cadherin in the nucleus were found between the groups. However, a significantly higher expression rate of cytoplasmic E-cadherin was found in group 1 (N-methyl-N-nitrosourea alone) compared to group 3 (magnetic field exposure alone) (remark EMF-Portal: no results were shown for histological analysis).
The authors conclude that a chronic exposure of rats to a 50 Hz magnetic field with 5 mT causes significant alterations in the cytoplasmic expression of E-cadherin in the colon.

Study character:

Study funded by

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