To study the possibility that a sinusoidal 50 Hz magnetic field with a magnetic flux density of 0.5 mT can induce variations in the expression of cell adhesion molecules in two human osteosarcoma cell lines.
|Chamber||Incubator maintained at 37°C.|
|Setup||25 cm² tissue culture flask kept in the incubator. The coils were also located in the incubator.|
|Additional info||Sham exposures were performed in the same incubator but inside a µ-metal cylinder(30 cm long x 23.5 cm diameter) with AC MF 0.84 µT and static component 0.22 µT. Control sample separate incubator with ambient AC MF 0.36 µT and static MF 40.2 µT.|
The data demonstrated that no variations in cell surface morphology and cell death occurred between control and exposed cells in both cell lines, while significant changes were revealed in cell growth and fibronectin and CD44 expression in MG-63 cells.
The findings are discussed in view of the important role that cell adhesion molecules play in controlling various cancer cell functions, particularly proliferation and metastasis.