Study type: Epidemiological study (observational study)

Pooled analysis of Swedish case-control studies during 1997-2003 and 2007-2009 on meningioma risk associated with the use of mobile and cordless phones. epidem.

Published in: Oncol Rep 2015; 33 (6): 3093-3098

Aim of study (acc. to author)

A pooled analysis of case-control studies on meningioma and use of mobile phones and cordless phones was conducted in Sweden.

Further details

Following studies are included: The first case-control study covering the period 1997-2000 is published in the publications Hardell et al (2002) and Hardell et al (2003). The second study covering the period 2000-2003 is published in Hardell et al (2005) concerning benign brain tumors and in Hardell et al (2006) concerning malignant brain tumors. A pooled analysis of these studies is published in Hardell et al (2006). The more recent case-control study on brain tumors was conducted in the period 2007-2009. The results of this new study on meningioma are published in Carlberg et al (2013). The results of the pooled analysis for acoustic neuroma, 1997-2003 and 2007-2009, are available in the publication Hardell et al (2013).

Endpoint/type of risk estimation

Type of risk estimation: (odds ratio (OR))

Exposure

Assessment

Exposure groups

Group Description
Reference group 1 unexposed
Group 2 analog mobile phone > 1 year latency period
Group 3 analog mobile phone > 1- to 5-year latency period
Group 4 analog mobile phone > 5- to 10-year latency period
Group 5 analog mobile phone > 10- to 15-year latency period
Group 6 analog mobile phone > 15- to 20-year latency period
Group 7 analog mobile phone > 20- to 25 -year latency period
Group 8 analog mobile phone > 25-year latency period
Group 9 digital (2G, 3G) mobile phone > 1 year latency period
Group 10 digital (2G, 3G) mobile phone > 1- to 5-year latency period
Group 11 digital (2G, 3G) mobile phone > 5- to 10-year latency period
Group 12 digital (2G, 3G) mobile phone > 10- to 15-year latency period
Group 13 digital (2G, 3G) mobile phone > 15- to 20-year latency period
Group 14 digital (2G, 3G) mobile phone > 20- to 25 -year latency period
Group 15 digital (2G, 3G) mobile phone > 25-year latency period
Group 16 mobile phone > 1 year latency period
Group 17 mobile phone > 1- to 5-year latency period
Group 18 mobile phone > 5- to 10-year latency period
Group 19 mobile phone > 10- to 15-year latency period
Group 20 mobile phone > 15- to 20-year latency period
Group 21 mobile phone > 20- to 25-year latency period
Group 22 mobile phone > 25-year latency period
Group 23 cordless phone > 1 year latency period
Group 24 cordless phone > 1- to 5-year latency period
Group 25 cordless phone > 5- to 10-year latency period
Group 26 cordless phone > 10- to 15-year latency period
Group 27 cordless phone > 15- to 20-year latency period
Group 28 cordless phone > 20- to 25-year latency period
Group 29 cordless phone > 25-year latency period
Group 30 wireless phone (mobile phones and cordless phones) > 1 year latency period
Group 31 wireless phone > 1- to 5-year latency period
Group 32 wireless phone > 5- to 10-year latency period
Group 33 wireless phone > 10- to 15-year latency period
Group 34 wireless phone > 15- to 20-year latency period
Group 35 wireless phone > 20- to 25-year latency period
Group 36 wireless phone > 25-year latency period
Group 37 cumulative use, 1st quartile: 1-122 h
Group 38 cumulative use, 2nd quartile: 123-511 h
Group 39 cumulative use, 3rd quartile: 512-1486 h
Group 40 cumulative use, 4th quartile: > 1486 h

Population

Case group

Control group

Study size

Cases Controls
Participants 1,625 3,530
Statistical analysis method: (adjustment: )

Conclusion (acc. to author)

Overall, no association between meningioma risk and use of mobile phone or cordless phones was found. In the highest exposure group (group 40: cumulative use of more than 1,436 h), a statistically non-significant increased risk was found for mobile phones (OR 1.2, Cl 0.9-1.6) and a statistically significant increased risk was observed for cordless phones (OR l.7, Cl 1.3-2.2). Among persons with a cumulative use of more than 3,358 h, a somewhat higher risk was found (mobile phones: OR 1.5, Cl 0.99-2.1; cordless phones: OR 2.0, Cl 1.4-2.8). In addition, the longest latency time gave somewhat increased risk for both phone types although the result was not statistically significant. There was no association for ipsilateral use or anatomical tumor location.
The authors concluded that the findings showed somewhat increased risk among heavy users of mobile phones and cordless phones. Since meningioma is generally a slow-growing tumor, longer latency period is necessary for definitive conclusions.

Study funded by

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