Study type: Epidemiological study (observational study)

The Intracranial Distribution of Gliomas in Relation to Exposure From Mobile Phones: Analyses From the INTERPHONE Study epidem.

Published in: Am J Epidemiol 2016; 184 (11): 818-828

Aim of study (acc. to author)

A case-only analysis was conducted to investigate the association between mobile phone use and glioma using information that included tumor localization data from the INTERPHONE Study.

Further details

A 3-dimensional point process model of Grell et al. (2015) was applied to analyze the tumor localization data. This method provides an alternative to previously used epidemiologic research designs when the localization is included in the investigation of brain tumors and mobile phone use.
Regular use of a mobile phone was defined as at least once a week for at least six months.

Endpoint/type of risk estimation

Type of risk estimation:



Exposure groups

Group Description
Reference group 1 duration of mobile phone use: < 6 years
Group 2 duration of mobile phone use: ≥ 6 years
Reference group 3 cumulative mobile phone use: < 200 hours
Group 4 cumulative mobile phone use: ≥ 200 hours
Reference group 5 cumulative number of calls: < 4,000
Group 6 cumulative number of calls: ≥ 4,000


Study size

Type Value
Total 2,700
Eligible 1,530
Evaluable 792
Statistical analysis method:

Results (acc. to author)

A statistically significant association between the intracranial distribution of gliomas and the selfreported location of the mobile phone was observed, in the sense that more gliomas occurred closer to the ear on the side of the head where the mobile phone was reported to have been used the most. The association was independent of the cumulative call time and cumulative number of calls, making it less likely that the association observed is caused by mobile phone use.

Limitations (acc. to author)

The model used reported side of mobile phone use, which is potentially influenced by recall bias.

Study funded by

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