Epidemiological study (observational study)

Use of mobile phones in Norway and risk of intracranial tumours.

Published in: Eur J Cancer Prev 2007; 16 (2): 158-164

Aim of study (acc. to author)

A population-based case-control study was conducted in Norway to test the hypothesis that use of mobile phones increases the risk of gliomas, meningiomas and acoustic neuromas. This study is part of the INTERPHONE project.

Further details

Regular use was defined as use of a cellular telephone at least once a week for 6 months or more.

Endpoint/type of risk estimation

Type of risk estimation:
  • incidence
(odds ratio (OR))

Exposure

Assessment

Exposure groups

Reference group 1 no or irregular use
Group 2 regular use
Group 3 duration of regular use: < 2 years
Group 4 duration of regular use: 2 - 5 years
Group 5 duration of regular use: ≥ 6 years
Group 6 time since first regular use: < 2 years
Group 7 time since first regular use: 2 - 5 years
Group 8 time since first regular use: ≥ 6 years
Group 9 cumulative use: < 17 hours
Group 10 cumulative use: 17 - 424 hours
Group 11 cumulative use: ≥ 425 hours
Group 12 cumulative use adjusted for handsfree: < 17 hours
Group 13 cumulative use adjusted for handsfree: 17 - 424 hours
Group 14 cumulative use adjusted for handsfree: ≥ 425 hours
Group 15 cumulative number of calls: < 400
Group 16 cumulative number of calls: 400 - 6999
Group 17 cumulative number of calls: ≥ 7000
Group 18 digital phones, regular use
Group 19 digital phones, time since first regular use: < 2 years
Group 20 digital phones, time since first regular use: 2 - 5 years
Group 21 digital phones, time since first regular use: ≥ 6 years
Group 22 analog phones, regular use
Group 23 analog phones, time since first regular use: < 6 years
Group 24 analog phones, time since first regular use: ≥ 6 years
Reference group 25 ipsilateral, never or rare use or use or use on opposite side to tumour
Group 26 ipsilateral, regular use
Group 27 ipsilateral, duration of regular use: < 2 years
Group 28 ipsilateral, duration of regular use: 2 - 5 years
Group 29 ipsilateral, duration of regular use: ≥ 6 years
Group 30 ipsilateral, time since first regular use: < 2 years
Group 31 ipsilateral, time since first regular use: 2 - 5 years
Group 32 ipsilateral, time since first regular use: ≥ 6 years
Reference group 33 contralateral, never or rare use or use on same side as tumour
Group 34 contralateral, regular use
Group 35 contralateral, duration of regular use: < 2 years
Group 36 contralateral, duration of regular use: 2 - 5 years
Group 37 contralateral, duration of regular use: ≥ 6 years
Group 38 contralateral, time since first regular use: < 2 years
Group 39 contralateral, time since first regular use: 2 - 5 years
Group 40 contralateral, time since first regular use: ≥ 6 years

Population

  • Group:
    • men
    • women
  • Observation period: 2001 - 2002
  • Study location: Norway (south/east and western/middle parts)

Case group

Control group

  • Selection:
    • population-based
  • Matching:
    • sex
    • age
    • area
    • educational level

Study size

Cases Controls
Participants 541 358
Participation rate 74 69
Statistical analysis method:
  • logistic regression
( adjustment:
  • age
  • sex
  • residential area
  • education
)

Conclusion (acc. to author)

No association was found between the use of mobile phones and the risk of gliomas, meningiomas or acoustic neuroma. The laterality of mobile phone use did not correlate with the location of the tumours.

Limitations (acc. to author)

The observation time was too short to detect long-term effects of mobile phone use.

Study funded by

  • European Union (EU)/European Commission
  • GSM Association, UK/Ireland
  • Mobile Manufacturers Forum (MMF), Belgium
  • International Union against Cancer (UICC; Union Internationale Contre le Cancer), Switzerland
  • Quality of Life and Management of Living Resources program of European Union

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