研究のタイプ: 疫学研究 (observational study)

[携帯電話およびコードレス電話の使用に関連した髄膜腫に関する1997-2003年および2007-2009年のスウェーデンの症例対照研究のプール分析] epidem.

Pooled analysis of Swedish case-control studies during 1997-2003 and 2007-2009 on meningioma risk associated with the use of mobile and cordless phones.

掲載誌: Oncol Rep 2015; 33 (6): 3093-3098

この論文は、著者らが以前に実施・報告した携帯電話およびコードレス電話の使用と脳腫瘍に関する1997-2003年および2007-2009年の症例対照研究から、髄膜腫についてのプール分析を行った。2つの症例対照研究は、全ての脳腫瘍の症例とその人口ベースの対照(性別、年齢でマッチング)からなる。髄膜腫のプールデータに関する条件無しロジスティック回帰分析には、元の研究の全ての参照グループを用いた。結果として、髄膜腫症例1625、対照3530を分析した;全体としては、携帯電話およびコードレス電話の使用との関連は見られなかったが、ヘビーユーザで若干のリスク上昇が示唆された、と報告している。

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研究の目的(著者による)

A pooled analysis of case-control studies on meningioma and use of mobile phones and cordless phones was conducted in Sweden.

詳細情報

Following studies are included: The first case-control study covering the period 1997-2000 is published in the publications Hardell et al (2002) and Hardell et al (2003). The second study covering the period 2000-2003 is published in Hardell et al (2005) concerning benign brain tumors and in Hardell et al (2006) concerning malignant brain tumors. A pooled analysis of these studies is published in Hardell et al (2006). The more recent case-control study on brain tumors was conducted in the period 2007-2009. The results of this new study on meningioma are published in Carlberg et al (2013). The results of the pooled analysis for acoustic neuroma, 1997-2003 and 2007-2009, are available in the publication Hardell et al (2013).

影響評価項目/リスク推定のタイプ

リスク推定のタイプ: (オッズ比(OR))

ばく露

ばく露評価

ばく露集団

グループ 説明
参照集団 1 unexposed
集団 2 analog mobile phone > 1 year latency period
集団 3 analog mobile phone > 1- to 5-year latency period
集団 4 analog mobile phone > 5- to 10-year latency period
集団 5 analog mobile phone > 10- to 15-year latency period
集団 6 analog mobile phone > 15- to 20-year latency period
集団 7 analog mobile phone > 20- to 25 -year latency period
集団 8 analog mobile phone > 25-year latency period
集団 9 digital (2G, 3G) mobile phone > 1 year latency period
集団 10 digital (2G, 3G) mobile phone > 1- to 5-year latency period
集団 11 digital (2G, 3G) mobile phone > 5- to 10-year latency period
集団 12 digital (2G, 3G) mobile phone > 10- to 15-year latency period
集団 13 digital (2G, 3G) mobile phone > 15- to 20-year latency period
集団 14 digital (2G, 3G) mobile phone > 20- to 25 -year latency period
集団 15 digital (2G, 3G) mobile phone > 25-year latency period
集団 16 mobile phone > 1 year latency period
集団 17 mobile phone > 1- to 5-year latency period
集団 18 mobile phone > 5- to 10-year latency period
集団 19 mobile phone > 10- to 15-year latency period
集団 20 mobile phone > 15- to 20-year latency period
集団 21 mobile phone > 20- to 25-year latency period
集団 22 mobile phone > 25-year latency period
集団 23 cordless phone > 1 year latency period
集団 24 cordless phone > 1- to 5-year latency period
集団 25 cordless phone > 5- to 10-year latency period
集団 26 cordless phone > 10- to 15-year latency period
集団 27 cordless phone > 15- to 20-year latency period
集団 28 cordless phone > 20- to 25-year latency period
集団 29 cordless phone > 25-year latency period
集団 30 wireless phone (mobile phones and cordless phones) > 1 year latency period
集団 31 wireless phone > 1- to 5-year latency period
集団 32 wireless phone > 5- to 10-year latency period
集団 33 wireless phone > 10- to 15-year latency period
集団 34 wireless phone > 15- to 20-year latency period
集団 35 wireless phone > 20- to 25-year latency period
集団 36 wireless phone > 25-year latency period
集団 37 cumulative use, 1st quartile: 1-122 h
集団 38 cumulative use, 2nd quartile: 123-511 h
集団 39 cumulative use, 3rd quartile: 512-1486 h
集団 40 cumulative use, 4th quartile: > 1486 h

調査対象集団

症例集団

対照集団

調査規模

症例 対照
参加者 1,625 3,530
統計学的分析方法: (調整: )

結論(著者による)

Overall, no association between meningioma risk and use of mobile phone or cordless phones was found. In the highest exposure group (group 40: cumulative use of more than 1,436 h), a statistically non-significant increased risk was found for mobile phones (OR 1.2, Cl 0.9-1.6) and a statistically significant increased risk was observed for cordless phones (OR l.7, Cl 1.3-2.2). Among persons with a cumulative use of more than 3,358 h, a somewhat higher risk was found (mobile phones: OR 1.5, Cl 0.99-2.1; cordless phones: OR 2.0, Cl 1.4-2.8). In addition, the longest latency time gave somewhat increased risk for both phone types although the result was not statistically significant. There was no association for ipsilateral use or anatomical tumor location.
The authors concluded that the findings showed somewhat increased risk among heavy users of mobile phones and cordless phones. Since meningioma is generally a slow-growing tumor, longer latency period is necessary for definitive conclusions.

研究助成

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