To determine whether chronic, low-level exposure of mammary tumor-prone mice to 2450 MHz radiofrequency radiation promotes an earlier onset (decreased latency), a greater total incidence, or a faster growth rate of mammary tumors.
|Chamber||The waveguides were housed in a room (5.49 m square) maintained at 24 ± 1°C and 50 ± 10% humidity.|
|Setup||The cages housing two mice were made of Plexiglas with 5-mm Plexiglas rods on the floor spaced 0.75 cm apart and oriented perpendicular to the individual waveguide (a copper mesh enclosure) [Guy et al., 1979]. They provided a floor area of 143 cm² per animal.|
|Sham exposure||A sham exposure was conducted.|
|Additional info||Mice were randomly assigned to RF and sham exposure groups (100 each).|
The results indicate that under these experimental conditions, long-term, low-level exposure of mammary tumor-prone mice to 2450 MHz radiofrequency did not affect mammary tumor incidence, latency to mammary tumor onset, mammary tumor growth rate, or survivorship when compared with sham-irradiated controls. Histopathological examination revealed no significant differences in numbers of malignant, metastatic, or benign neoplasms between the two groups. A significant greater incidence of alveolar-bronchiolar adenoma in the sham-irradiated animals was the only exception. Survival analysis showed no significant difference between sham and irradiated mice.