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Epidemiological study (observational study)

Work related etiology of amyotrophic lateral sclerosis (ALS): a meta-analysis.

Published in: Ann Ig 2014; 26 (5): 456-472

Aim of study (acc. to author)

The association between amyotrophic lateral sclerosis and occupational exposure to extremely low-frequency magnetic fields and other potential risk factors such as chemicals was evaluated in a meta-analysis.

Further details

Following studies were included: Davanipour et al (2007), Noonan et al (2002), Park et al (2005), Hakansson et al (2003), Savitz et al (1998), Parlett et al (2011), Johansen (2000), Röösli et al (2007), and Sorahan and Kheifets (2007).

Endpoint/type of risk estimation

Type of risk estimation:
  • incidence
  • mortality
  • prevalence
(relative risk (RR))

Exposure

Assessment

Population

  • Group:
    • men
    • women
  • Study location: USA, Switzerland, Sweden, Denmark, UK
Statistical analysis method:
  • heterogeneity test, fixed- and random-effects models

Conclusion (acc. to author)

An increased risk for amyotrophic lateral sclerosis and occupational exposure to extremely low frequency magnetic fields was observed (RR 1.33, CI 0.67-4.14). Restricting the analysis on the two studies with exposure measurements, the relative risk was 1.6 (CI 0.59-5.34).
The authors concluded that a slight and non-significant association between amyotrophic lateral sclerosis and occupational exposure to extremely low frequency magnetic fields was found.

Study funded by

  • Istituto Nazionale Per L'Assicurazione Contro Gli Infortuni Sul Lavoro (INAIL; Italian Workers' Compensation Authority), Italy

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