The possible effects of a 60 Hz linear sinusoidal magnetic field on central nervous system/peripheral nervous system tumor promotion in rats exposed to the chemical mutagen ethylnitrosourea (ENU) should be investigated in this in vivo study.
Altogether 400 female rats were examined in eight groups (50 animals each): 1.) no treatment, 2.) only ENU, 3.) ENU plus sham exposure, 4.-7.) ENU plus magnetic field at four different magnetic flux densities (2, 20, 200 and 2000 µT), and 8.) positive control (TPA treated animals).
| Exposure | Parameters |
|---|---|
| Exposure 1: 60 Hz |
|
rats were treated in 8 groups: i) saline injection ii) 5 mg/kg ENU injection iii) 5 mg/kg ENU injection + sham EMF exposure iv) 5 mg/kg ENU injection + exposure to 2 µT v) 5 mg/kg ENU injection + exposure to 20 µT vi) 5 mg/kg ENU injection + exposure to 200 µT vii) 5 mg/kg ENU injection + exposure to 2000 µT viii) 5 mg/kg ENU injection + 10 µg/kg TPA injection
| Exposure source | |
|---|---|
| Chamber | 20 identical exposure modules, each containing 8 cages (3 rats per cage), arranged in 5 rows of 4 modules |
| Setup | rectangular solenoid |
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 2,000 µT | maximum | measured | - | - |
| magnetic flux density | 200 µT | - | measured | - | - |
| magnetic flux density | 20 µT | - | measured | - | - |
| magnetic flux density | 2 µT | minimum | measured | - | - |
The exposure to 60 Hz linear sinusoidal magnetic fields had no effect on the survival of female rats or on the tumor incidence of the central nervous system/peripheral nervous system.
These results indicate that magnetic fields have no promoting effect on neurogenic tumors in the female rats exposed to the chemical mutagen ENU.
This website uses cookies to provide you the best browsing experience. By continuing to use this website you accept our use of cookies.
