To study the effects of chlorpromazine, methysergide, and propranolol on thermal responses to 2.8 GHz radiofrequency irradiation in anesthetized rats (this frequency is characteristic of high power stationary tracking radars for military applications).
The authors hypothesized that propranolol should decrease the hyperthermic response to radiofrequency irradiation, while methysergide should increase the response.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
2.8 GHz
Modulation type:
CW
Exposure duration:
until colonical temperature rise of 1°C
|
|
| Frequency | 2.8 GHz |
|---|---|
| Charakteristic | |
| Exposure duration | until colonical temperature rise of 1°C |
| Additional info | The animals were exposed in H orientation (long axis of the animal parallel magnetic field) |
| Modulation type | CW |
|---|
| Exposure source | |
|---|---|
| Setup | The animals were positioned on a on a Plexiglas holder |
| Additional info | The temperature rise times before chlorpromazine, propranolol, methysergide and saline administration were 5.9 ± 0.4 min, 5.8 ± 0.6 min, 5.6 ± 0.4 min, 6.1 ± 0.4 min respectively and 6.9 ± 0.4 min, 6.1 ± 0.4 min, 6.3 ± 0.6 min and 6.7 ± 0.2 min after chlorpromazine, propranolol, methysergide and saline administration. The recovery times before chlorpromazine, propranolol, methysergide and saline administration were 16.7 ± 1.7 min, 14.3 ± 0.8 min, 15.2 ± 1.7 min, 14.3 ± 1.3 min respectively and 12.5 ± 1.6 min, 14.3 ± 0.8 min, 15.2 ± 1.7 min and 12.3 ± 0.8 min after chlorpromazine, propranolol, methysergide and saline administration |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| power density | 600 W/m² | - | measured | - | 14 W/kg corresponding SAR value |
During intermittent irradiation at an average power density of 60 mW/cm², when colonic temperature was not allowed to rise above 39.5°C, none of the pharmacological agents had any significant effects on thermal responses. When irradiation was continued until lethal temperatures resulted, rats which were administered chlorpromazine, methysergide, or propranolol exhibited significantly shorter survival times than saline-treated rats. Propranolol administration caused the greatest decrease in survival time and resulted in a significantly lower lethal temperature than that which occurred in saline-treated rats.
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