Study type: Medical/biological study (experimental study)

Increased susceptibility to radiofrequency radiation due to pharmacological agents. med./bio.

Published in: Aviat Space Environ Med 1984; 55 (11): 1036-1040

Aim of study (acc. to author)

To study the effects of chlorpromazine, methysergide, and propranolol on thermal responses to 2.8 GHz radiofrequency irradiation in anesthetized rats (this frequency is characteristic of high power stationary tracking radars for military applications).

Background/further details

The authors hypothesized that propranolol should decrease the hyperthermic response to radiofrequency irradiation, while methysergide should increase the response.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.8 GHz
Modulation type: CW
Exposure duration: until colonical temperature rise of 1°C

Exposure 1

Main characteristics
Frequency 2.8 GHz
Charakteristic
Exposure duration until colonical temperature rise of 1°C
Additional info The animals were exposed in H orientation (long axis of the animal parallel magnetic field)
Modulation
Modulation type CW
Exposure setup
Exposure source
Setup The animals were positioned on a on a Plexiglas holder
Additional info The temperature rise times before chlorpromazine, propranolol, methysergide and saline administration were 5.9 ± 0.4 min, 5.8 ± 0.6 min, 5.6 ± 0.4 min, 6.1 ± 0.4 min respectively and 6.9 ± 0.4 min, 6.1 ± 0.4 min, 6.3 ± 0.6 min and 6.7 ± 0.2 min after chlorpromazine, propranolol, methysergide and saline administration. The recovery times before chlorpromazine, propranolol, methysergide and saline administration were 16.7 ± 1.7 min, 14.3 ± 0.8 min, 15.2 ± 1.7 min, 14.3 ± 1.3 min respectively and 12.5 ± 1.6 min, 14.3 ± 0.8 min, 15.2 ± 1.7 min and 12.3 ± 0.8 min after chlorpromazine, propranolol, methysergide and saline administration
Parameters
Measurand Value Type Method Mass Remarks
power density 600 W/m² - measured - 14 W/kg corresponding SAR value

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure

Main outcome of study (acc. to author)

During intermittent irradiation at an average power density of 60 mW/cm², when colonic temperature was not allowed to rise above 39.5°C, none of the pharmacological agents had any significant effects on thermal responses. When irradiation was continued until lethal temperatures resulted, rats which were administered chlorpromazine, methysergide, or propranolol exhibited significantly shorter survival times than saline-treated rats. Propranolol administration caused the greatest decrease in survival time and resulted in a significantly lower lethal temperature than that which occurred in saline-treated rats.

Study character:

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