研究のタイプ: 医学/生物学の研究 (experimental study)

[薬剤による無線周波放射の感受性上昇] med./bio.

Increased susceptibility to radiofrequency radiation due to pharmacological agents.

掲載誌: Aviat Space Environ Med 1984; 55 (11): 1036-1040

この研究は、2.8 GHz電磁放射(RFR)の断続的ばく露中の麻酔処置されたラットにおける熱的応答に対し、薬剤クロルプロマジン、メチルセルギド、およびプロプラノロール)が与える影響を調べた。平均電力密度60 mW / cm 2(平均SAR 14 W / kg)の2.8 GHzのばく露を断続することで結腸温度が39.5℃を超えないようにした場合、いずれの薬剤有意な影響を及ぼさなかった;致死温度に達するまでばく露を続けた場合、クロルプロマジン、メチセルギド、またはプロプラノロールを投与されたラットは、食塩水投与のラットより有意に生存期間が短くなった;プロプラノロール投与ラットは、最も短い生存期間となり、致死温度も食塩水投与のラットより有意に低かった、と報告している。

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研究目的(著者による)

To study the effects of chlorpromazine, methysergide, and propranolol on thermal responses to 2.8 GHz radiofrequency irradiation in anesthetized rats (this frequency is characteristic of high power stationary tracking radars for military applications).

詳細情報

The authors hypothesized that propranolol should decrease the hyperthermic response to radiofrequency irradiation, while methysergide should increase the response.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.8 GHz
Modulation type: CW
ばく露時間: until colonical temperature rise of 1°C

ばく露1

主たる特性
周波数 2.8 GHz
特性
  • far field
ばく露時間 until colonical temperature rise of 1°C
Additional information The animals were exposed in H orientation (long axis of the animal parallel magnetic field)
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 The animals were positioned on a on a Plexiglas holder
Additional information The temperature rise times before chlorpromazine, propranolol, methysergide and saline administration were 5.9 ± 0.4 min, 5.8 ± 0.6 min, 5.6 ± 0.4 min, 6.1 ± 0.4 min respectively and 6.9 ± 0.4 min, 6.1 ± 0.4 min, 6.3 ± 0.6 min and 6.7 ± 0.2 min after chlorpromazine, propranolol, methysergide and saline administration. The recovery times before chlorpromazine, propranolol, methysergide and saline administration were 16.7 ± 1.7 min, 14.3 ± 0.8 min, 15.2 ± 1.7 min, 14.3 ± 1.3 min respectively and 12.5 ± 1.6 min, 14.3 ± 0.8 min, 15.2 ± 1.7 min and 12.3 ± 0.8 min after chlorpromazine, propranolol, methysergide and saline administration
パラメータ
測定量 種別 Method Mass 備考
電力密度 600 W/m² - 測定値 - 14 W/kg corresponding SAR value

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中

研究の主なアウトカム(著者による)

During intermittent irradiation at an average power density of 60 mW/cm², when colonic temperature was not allowed to rise above 39.5°C, none of the pharmacological agents had any significant effects on thermal responses. When irradiation was continued until lethal temperatures resulted, rats which were administered chlorpromazine, methysergide, or propranolol exhibited significantly shorter survival times than saline-treated rats. Propranolol administration caused the greatest decrease in survival time and resulted in a significantly lower lethal temperature than that which occurred in saline-treated rats.

研究の種別:

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