To study the effects of chlorpromazine, amitriptyline, and haloperidol on thermal responses in anesthetized rats exposed to 2.8 GHz radiofrequency irradiation (this frequency is characteristic of high power stationary tracking radars for military applications). Pharmacological agents which may modify thermoregulation are of interest, because an increase in body temperature is a primary effect of exposure to high levels of radiofrequency irradiation.
*The exposure was discontinued when the colonic temperature increased to 39.5?C and it was initiated again when the temperature returned to 38.5?C. This procedure was continued for 4 cycles (drugs were administered before the 4th cycle)
|Pulse width||2 µs|
|Repetition frequency||500 Hz|
Administration of chlorpromazine (5 mg/kg) resulted in a slower rate of colonic temperature rise during irradiation and a faster return to baseline temperature when exposure was discontinued. Administration of amitriptyline (10 mg/kg), haloperidol (0.1 mg/kg), or saline did not significantly affect thermal responses. A more rhythmic pattern of respiration was revealed following chlorpromazine administration; the change in pattern was not observed after amitriptyline, haloperidol, or saline administration. The findings indicate that acute administration of chlorpromazine can counteract hyperthermia during radiofrequency irradiation, when colonic temperature is not allowed to rise above 39.5°C.