Study type: Medical/biological study (experimental study)

Thermal responses to 5.6-GHz radiofrequency radiation in anesthetized rats: effect of chlorpromazine. med./bio.

Published in: Physiol Chem Phys Med NMR 1988; 20 (2): 135-143

Aim of study (acc. to author)

To determine if chlorpromazine affects the thermal responses, heart rate, blood pressure, and respiratory rate of anesthetized rats during exposure to 5.6 GHz radiofrequency irradiation (this frequency is characteristic of high-power stationary tracking radars for military applications and of naval ship radars).

Background/further details

Experiments were performed that resulted in two stages: 1) exposures were performed that resulted in colonic temperture increase from 38.5 to 39.5°C, and 2) radiofrequency irradiation was initiated at 38.5°C and continued until death body temperatures were attained.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 5.6 GHz
Modulation type: CW
Exposure duration: until temperature rise of 1°C
  • power density: 60 mW/cm² average over time
  • SAR: 12 W/kg average over time (whole body)
Exposure 2: 5.6 GHz
Modulation type: CW
Exposure duration: until lethal colonic temperature; 29.5 +/- 2.6 min without saline treatment; 36.9 +/- 2.2 min saline-treated
  • power density: 60 mW/cm² average over time
  • SAR: 12 W/kg average over mass (whole body)

Exposure 1

Main characteristics
Frequency 5.6 GHz
Type
Charakteristic
Exposure duration until temperature rise of 1°C
Additional info exposure started at a colonic temperature of 38.5°C; exposure was discontinued when the colonic temperature increased to 39.5°C and it was initiated again when the temperature returned to 38.5°C; this procedure was continued for 6 cycles (drugs were administered before the 4th cycle).
Modulation
Modulation type CW
Exposure setup
Exposure source
Setup long axis of animal parallel to the magnetic field
Parameters
Measurand Value Type Method Mass Remarks
power density 60 mW/cm² average over time measured - -
SAR 12 W/kg average over time calculated whole body -

Exposure 2

Main characteristics
Frequency 5.6 GHz
Type
Charakteristic
Exposure duration until lethal colonic temperature; 29.5 +/- 2.6 min without saline treatment; 36.9 +/- 2.2 min saline-treated
Modulation
Modulation type CW
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
power density 60 mW/cm² average over time measured - -
SAR 12 W/kg average over mass calculated whole body -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure

Main outcome of study (acc. to author)

After acute administration of chlorpromazine, body temperature exhibited a faster return to baseline temperature when irradiation was discontinued. When irradiation was initiated at 38.5°C and continued until lethal temperatures resulted, chlorpromazine-treated rats exhibited significantly shorter survival times than saline-treated rats. Thus, although chlorpromazine enhanced thermoregulatory efficiency at colonic temperatures below 39.5°C, the drug produced increased susceptibility to terminal radiofrequency irradiation.
The present findings, when compared to previous studies of irradiation at 2.8 GHz (e.g. publication 4486), suggest that the effects of chlorpromazine on thermal responses to radiofrequency irradiation during intermittent and terminal exposure are similar at both 2.8 and 5.6 GHz.

Study character:

Study funded by

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