この研究は、2.8 GHz電磁放射(RFR)にばく露した麻酔ラットの熱的応答に対するクロルプロマジン、アミトリプチリン、ハロペリドールの影響を調べた。平均電力密度60 mW / cm 2(平均の全身平均SAR 14 W / kg)で、ばく露時間は、結腸温度が38.5℃から39.5℃に上昇するまでとした。その結果、クロルプロマジン(5 mg/ kg)投与の場合、ばく露中の結腸温度上昇速度は遅くなり、ばく露中断時のベースライン温度への復帰は早まった;アミトリプチリン(10 mg/ kg)、ハロペリドール(0.1 mg/ kg)、または食塩水投与の場合、熱的応答に有意な変化は観察されなかった;クロルプロマジン投与後に、呼吸パターンはより周期的になったが、アミトリプチリン、ハロペリドール、または食塩水の投与後にこのパターン変化は見られなかった、と報告している。
The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →
To study the effects of chlorpromazine, amitriptyline, and haloperidol on thermal responses in anesthetized rats exposed to 2.8 GHz radiofrequency irradiation (this frequency is characteristic of high power stationary tracking radars for military applications). Pharmacological agents which may modify thermoregulation are of interest, because an increase in body temperature is a primary effect of exposure to high levels of radiofrequency irradiation.
*The exposure was discontinued when the colonic temperature increased to 39.5?C and it was initiated again when the temperature returned to 38.5?C. This procedure was continued for 4 cycles (drugs were administered before the 4th cycle)
周波数 | 2.8 GHz |
---|---|
タイプ |
|
特性 |
|
ばく露時間 | intermittent* |
Modulation type | pulsed |
---|---|
Pulse width | 2 µs |
Repetition frequency | 500 Hz |
ばく露の発生源/構造 |
|
---|---|
チャンバの詳細 | Eccosorb RF-shielded anechoic chamber. |
Additional information | Animals exposed to H-orientation; long axis parallel to the magnetic field. |
Administration of chlorpromazine (5 mg/kg) resulted in a slower rate of colonic temperature rise during irradiation and a faster return to baseline temperature when exposure was discontinued. Administration of amitriptyline (10 mg/kg), haloperidol (0.1 mg/kg), or saline did not significantly affect thermal responses. A more rhythmic pattern of respiration was revealed following chlorpromazine administration; the change in pattern was not observed after amitriptyline, haloperidol, or saline administration. The findings indicate that acute administration of chlorpromazine can counteract hyperthermia during radiofrequency irradiation, when colonic temperature is not allowed to rise above 39.5°C.
このウェブサイトはクッキー(Cookies)を使って、最善のブラウジングエクスペリエンスを提供しています。あなたがこのウェブサイトを継続して使用することで、私たちがクッキーを使用することを許可することになります。