研究のタイプ: 医学/生物学の研究 (experimental study)

[無線周波放射への熱的反応に対する向精神薬の影響] med./bio.

Effects of psychotropic drugs on thermal responses to radiofrequency radiation.

掲載誌: Aviat Space Environ Med 1985; 56 (12): 1183-1188

この研究は、2.8 GHz電磁放射(RFR)にばく露した麻酔ラットの熱的応答に対するクロルプロマジン、アミトリプチリンハロペリドールの影響を調べた。平均電力密度60 mW / cm 2(平均の全身平均SAR 14 W / kg)で、ばく露時間は、結腸温度が38.5℃から39.5℃に上昇するまでとした。その結果、クロルプロマジン(5 mg/ kg)投与の場合、ばく露中の結腸温度上昇速度は遅くなり、ばく露中断時のベースライン温度への復帰は早まった;アミトリプチリン(10 mg/ kg)、ハロペリドール(0.1 mg/ kg)、または食塩水投与の場合、熱的応答に有意な変化は観察されなかった;クロルプロマジン投与後に、呼吸パターンはより周期的になったが、アミトリプチリンハロペリドール、または食塩水の投与後にこのパターン変化は見られなかった、と報告している。

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研究目的(著者による)

To study the effects of chlorpromazine, amitriptyline, and haloperidol on thermal responses in anesthetized rats exposed to 2.8 GHz radiofrequency irradiation (this frequency is characteristic of high power stationary tracking radars for military applications). Pharmacological agents which may modify thermoregulation are of interest, because an increase in body temperature is a primary effect of exposure to high levels of radiofrequency irradiation.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.8 GHz
Modulation type: pulsed
ばく露時間: intermittent*

General information

*The exposure was discontinued when the colonic temperature increased to 39.5?C and it was initiated again when the temperature returned to 38.5?C. This procedure was continued for 4 cycles (drugs were administered before the 4th cycle)

ばく露1

主たる特性
周波数 2.8 GHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 intermittent*
Modulation
Modulation type pulsed
Pulse width 2 µs
Repetition frequency 500 Hz
ばく露装置
ばく露の発生源/構造
  • model 2852 S band megnetron source and transmitted by model 644 antenna.
チャンバの詳細 Eccosorb RF-shielded anechoic chamber.
Additional information Animals exposed to H-orientation; long axis parallel to the magnetic field.
パラメータ
測定量 種別 Method Mass 備考
電力密度 600 W/m² mean 測定値 - -
SAR 14 mW/g mean 計算値 whole body -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中

研究の主なアウトカム(著者による)

Administration of chlorpromazine (5 mg/kg) resulted in a slower rate of colonic temperature rise during irradiation and a faster return to baseline temperature when exposure was discontinued. Administration of amitriptyline (10 mg/kg), haloperidol (0.1 mg/kg), or saline did not significantly affect thermal responses. A more rhythmic pattern of respiration was revealed following chlorpromazine administration; the change in pattern was not observed after amitriptyline, haloperidol, or saline administration. The findings indicate that acute administration of chlorpromazine can counteract hyperthermia during radiofrequency irradiation, when colonic temperature is not allowed to rise above 39.5°C.

研究の種別:

研究助成

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