To investigate whether the hypoalgesic effect of millimeter wave therapy in the cold water tail-flick test (cTFT) can be reproduced by exposure to millimeterwave of surgically deafferented skin areas.
Exposure duration: 15 min
|Exposure duration||15 min|
|Setup||mouse was restrained in a plastic tube with plantar surface of the paw uncovered for exposure and the murine tail placed outside the restrainer.|
|power density||150 W/m²||unspecified||unspecified||-||-|
Exposure of an intact paw to the millimeter waves resulted in a statistically significant hypoalgesia. The mice were able to resist cold noxious stimulation in the cTFT more than two times longer than control animals. The unilateral sciatic nerve transection completely abolished the hypoalgesic effect of the exposure. Thus, it is concluded that the millimeter waves - skin nerve endings interaction is the essential step in the initiation of biological effects caused by millimeter waves. Based on the results it is recommended that in order to obtain a maximum therapeutic effect, densely innervated skin areas (head, hands) need to be used in clinical practice.