Study type: Medical/biological study (experimental study)

The influence of long-term exposure of mice to randomly varied power frequency magnetic fields on their nocturnal melatonin secretion patterns med./bio.

By: de Bruyn L, de Jager L, Kuyl JM
Published in: Environ Res 2001; 85 (2): 115-121
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Aim of study (acc. to author)

To investigate the effects of a randomly varied (0.5 to 77 µT), 50 Hz magnetic field on nocturnal melatonin levels in mice.

Background/further details

Two different strains of mice were used in this study: A) AKR, a high risk leukemia strain, and B) BALB/c, a leukemia resistant strain. 10 pairs of mice of each strain were exposed, male offspring was exposed till their body mass was about 28-34 g (according to 2-4 months of age).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous 24 h/day from conception until adult age of 2 or 4 months

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration continuous 24 h/day from conception until adult age of 2 or 4 months
Exposure setup
Exposure source
Setup 2 sets of 4 square coils perpendicular to each other
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 77 µT effective value measured - -
magnetic flux density 500 nT effective value measured - -
magnetic flux density 2.75 µT mean measured - -
Additional parameter details

maximum rate change of 0.43 µT/s

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

No statistically significant differences in the nocturnal plasma melatonin levels between exposed and sham-exposed animals could be found.

Study character:

Study funded by

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