Study type: Medical/biological study (observational study)

Relationship between amyloid beta protein and melatonin metabolite in a study of electric utility workers. med./bio.

Published in: J Occup Environ Med 2002; 44 (8): 769-775

Aim of study (acc. to author)

To assess the relationship between occupational magnetic field exposure, the urinary melatonin metabolite 6-hydroxymelatoninsulfate and concentrations of amyloid beta protein, a protein (40-42 amino acids) associated with the lesions of Alzheimer's disease.

Background/further details

60 male employees from three electric utilities participated.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: during the first 3 days of the week

General information

Measurement of magnetic field due to occupation exposure of employees working at electrical distribution, generation, administration and maintenance utilities.

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Waveform
Exposure duration during the first 3 days of the week
Exposure setup
Additional info Male employees from electric power distribution and generation utilities served as high exposure groups while employees from administration and maintenance served as low exposure group.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 0.12 µT - measured - distribution and generation workers
magnetic flux density 0.06 µT - measured - administration and maintenance workers
magnetic flux density 0.3 µT mean measured - arithmetic mean for all workers
magnetic flux density 0.11 µT mean measured - geometric mean for all workers

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure

Main outcome of study (acc. to author)

Average amyloid beta protein levels were positively associated with categories of magnetic field exposure, but this relationship was weak and not statistically significant. The melatonin metabolite was inversely correlated with amyloid beta protein (amino acids 1-42) and the ratio of "amyloid beta protein (amino acids 1-42) to amyloid beta protein (amino acids 1-40)".

Study character:

Study funded by

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