Study type: Medical/biological study (experimental study)

Absence of microwave effect on blood-brain barrier permeability to [14C]sucrose in the conscious rat. med./bio.

Published in: Exp Neurol 1982; 75 (2): 299-307

Aim of study (acc. to author)

Examination of effect of continuous-wave or pulsed wave microwave energy on the cerebrovascular permeability area product for [14C]sucrose at the blood-brain barrier of rats.

Background/further details

The cerebrovascular permeability area product is the product of cerebrovascular permeability and capillary surface area per cubic centimeter of brain.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.8 GHz
Modulation type: CW
Exposure duration: continuous for 30 min
Exposure 2: 2.8 GHz
Modulation type: pulsed
Exposure duration: continuous for 30 min

Exposure 1

Main characteristics
Frequency 2.8 GHz
Type
Waveform
Exposure duration continuous for 30 min
Modulation
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 0.68 m
Chamber anechoic chamber (512 ft³) maintained at 27°C.
Setup rats were placed in a styrofoam form-fitting holder located 68 cm from the horn
Parameters
Measurand Value Type Method Mass Remarks
power density 10 mW/cm² unspecified - - -
power density 40 mW/cm² unspecified - - -

Exposure 2

Main characteristics
Frequency 2.8 GHz
Type
Waveform
Exposure duration continuous for 30 min
Modulation
Modulation type pulsed
Pulse width 2 µs
Repetition frequency 500 Hz
Exposure setup
Exposure source
Distance between exposed object and exposure source 0.68 m
Parameters
Measurand Value Type Method Mass Remarks
power density 1 mW/cm² unspecified - - -
power density 5 mW/cm² unspecified - - -
power density 10 mW/cm² unspecified - - -
power density 15 mW/cm² unspecified - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

Regardless of the power density level of the microwaves, the permeability area product for [14C]sucrose in any brain region was not significantly different from that in the sham-irradiated control animals. The findings indicate that microwave irradiation under the given experimental conditions does not damage the blood-brain barrier.

Study character:

Study funded by

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