Study type: Medical/biological study (experimental study)

Effects of radiofrequency radiation exposure on blood-brain barrier permeability in male and female rats. med./bio.

Published in: Electromagn Biol Med 2011; 30 (4): 253-260

Aim of study (acc. to author)

To study the effect of radiofrequency exposure on the permeability of the blood-brain barrier in male and female rats.

Background/further details

The right hemisphere, left hemisphere, cerebellum, and total brain were analyzed separately.
The animals were divided into six groups (n=9 per proup): 1) sham exposed female rats, 2) sham exposed male rats, 3) 0.9 GHz exposed females 4) 0.9 GHz exposed males, 5) 1.8 GHz exposed females, 6) 1.8 GHz exposed males.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 0.9 GHz
Modulation type: CW
Exposure duration: continuous for 20 min
Exposure 2: 1.8 GHz
Modulation type: CW
Exposure duration: continuous for 20 min

General information

The animals were treated in the following six groups: i) female sham exposure ii) male sham exposure iii) female exposure to 0.9 GHz iv) male exposure to 0.9 GHz v) female exposure to 1.8 GHz vi) male exposure to 1.8 GHz

Exposure 1

Main characteristics
Frequency 0.9 GHz
Type
Exposure duration continuous for 20 min
Modulation
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 10 cm
Setup rats were anesthetized during exposure; rats exposed individually with their body parallel to the E-field component of the RF-field
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 4.71 V/m - - - ± 0.02 V/m
SAR 4.26 mW/kg average over mass calculated 10 g brain tissue

Exposure 2

Main characteristics
Frequency 1.8 GHz
Type
Exposure duration continuous for 20 min
Modulation
Modulation type CW
Exposure setup
Exposure source
Distance between exposed object and exposure source 10 cm
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 4.92 V/m - - - ± 0.12 V/m
SAR 1.46 mW/kg average over mass calculated 10 g brain tissue

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No albumin extravasation was found in the brains of female rats after radiofrequency exposure. However, a significant increase in albumin extravasation was found in the brains of the exposed male rats when compared to sham exposed male animals.
These data suggest that 0.9 and 1.8 GHz radiofrequency exposure (continuous wave) at levels below the international limits can affect the vascular permeability in the brain of male rats.

Study character:

Study funded by

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