Study type: Medical/biological study (experimental study)

Magnetic field exposure increases cell proliferation but does not affect melatonin levels in the mammary gland of female Sprague Dawley rats. med./bio.

Published in: Cancer Res 2002; 62 (5): 1356-1363

Aim of study (acc. to author)

To investigate the effects of 50 Hz /100 µT magnetic field exposure on cell proliferation in mammary epithelium of rats. Furthermore, possible changes in melatonin levels in pineal gland and mammary tissue were investigated. An additional experiment with TPA (tetradecanoylphorbol acetate)-treatment was used for comparison with effects of magnetic field-exposure.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 24 h/day, 7 days/week, for 2 weeks

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 24 h/day, 7 days/week, for 2 weeks
Additional info horizontally polarized EMF
Exposure setup
Exposure source
  • not specified
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 100 µT effective value measured - -

Reference articles

  • Mevissen M et al. (1998): Acceleration of mammary tumorigenesis by exposure of 7,12-dimethylbenz[a]anthracene-treated female rats in a 50-Hz, 100-microT magnetic field: replication study.
  • Baum A et al. (1995): A histopathological study on alterations in DMBA-induced mammary carcinogenesis in rats with 50 Hz, 100 muT magnetic field exposure.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

Magnetic field exposure did not affect melatonin levels in pineal gland and mammary tissue. However, cell proliferation in mammary tissue was significantly enhanced by magnetic field exposure, as indicated by the used labeling techniques. Bromodeoxyuridine and Ki-67 labeling in mammary tissue was not affected by TPA treatment, but was increased in epithelial cells of the skin, particularly in hair follicles.

Study character:

Study funded by

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