To investigate whether simultaneous exposure of mouse leukemic cells to radiofrequency radiation at moderate power levels can affect the extent of mutagenesis caused by proflavine (a drug known to intercalate with DNA).
Modulation type: pulsed
Exposure duration: continuous for 4 h
Six exposure conditions: 37°C control, radio frequency exposure, temperature control exposure, proflavin treatment at 37°C, proflavin treatment with simultaneous radio frequency exposure and proflavin treatment with simultaneous temperature control.
|Pulse width||10 µs|
|Duty cycle||0.25 %|
|Packets per second||25,000|
|Repetition frequency||1 Hz|
|Distance between exposed object and exposure source||1.6 m|
|Chamber||anechoic chamber / 12 m x 6 m x 3 m|
|Setup||One bath was placed directly beneath the horn|
|Additional info||T-25 flasks were placed on the underside of the circular Styrofoam wheel, which was placed into a water bath. Two other water baths (at 37°C and for TC) were located at the far end of the anechoic chamber.|
|power density||870 W/m²||unspecified||measured||-||in Experiment 1 and 2.|
|power density||650 W/m²||unspecified||measured||-||in Experiment 3.|
|SAR||40 mW/g||mean||calculated||unspecified||in Experiment 3.|
|SAR||40.8 mW/g||mean||calculated||unspecified||in experiment 1 and 2, standard deviation of +/- 13.4 W/kg.|
In no case any indication of a statistically significant increase in the induced mutant frequency due to simultaneous exposure to radiofrequency radiation (RFR) and proflavine was found, as compared with the proflavine exposures alone. There was also no indication of any change in the colony-size distribution of the resulting mutant colonies, neigther. And there was no evidence in these experiments of any mutagenic action by the RFR alone.